Esopin 20 mg (Tablet (Enteric Coated))
Unit Price: ৳ 4.02 (5 x 10: ৳ 201.00)
Strip Price: ৳ 40.20
Medicine Details
Category | Details |
---|---|
Generic | Esomeprazole |
Company | Hallmark pharmaceuticals ltd |
Title
- Esopin 20 mg Tablet
Categories
- Heartburn Relief
- GERD Medication
- Erosive Esophagitis Treatment
- Ulcer Healing
Description
- Esomeprazole is a proton pump inhibitor used for the treatment of chronic heartburn, erosive esophagitis, Helicobacter pylori eradication, Zollinger-Ellison Syndrome, dyspepsia, and ulcers.
Dimensions
- N/A
ColorOptions
- N/A
Functions
- Relieves chronic heartburn
- Heals erosive esophagitis
- Maintains healing of erosive esophagitis
- Eradicates Helicobacter pylori infection
- Treats Zollinger-Ellison Syndrome
- Manages acid-related dyspepsia
- Heals duodenal and gastric ulcers
Materials
- Esomeprazole magnesium
TechnicalSpecifications
- Pharmacology:
- Suppresses gastric acid secretion
- Inhibits H+/K+-ATPase
- Provides better acid control
- Peak plasma levels occur at approximately 1.5 hours after oral administration
- Metabolized by the liver
- Systemic bioavailability is approximately 90%
- Metabolized by cytochrome P450 enzymes
- Plasma elimination half-life is approximately 1–1.5 hours
- Dosage:
- 20 mg or 40 mg oral dose for healing of erosive esophagitis
- 20 mg oral dose for maintenance of healing of erosive esophagitis
- 20 mg oral dose for symptomatic GERD
- 40 mg oral dose for Helicobacter pylori eradication
- 20-80 mg oral dose for Zollinger-Ellison Syndrome
- 20-40 mg oral dose for acid-related dyspepsia
- 20 mg oral dose for duodenal ulcer
- 20-40 mg oral dose for gastric ulcer
- Dosage for GERD with erosive esophagitis and risk reduction of rebleeding of ulcers via IV injection or infusion
DesignElements
- Tablet or capsule form
- Oral suspension
- IV injection or infusion
UsabilityFeatures
- Swallowed whole and taken one hour before a meal
- Administration via nasogastric or gastric tube for oral suspension
- IV injection must be administered intravenously over a period of at least 3 minutes
Absorption
- Peak plasma levels occur at approximately 1.5 hours after oral administration
Distribution
- 97% bound to plasma proteins
- Apparent volume of distribution at steady state in healthy volunteers is approximately 16 L
Metabolism
- Extensively metabolized in the liver by cytochrome P450 enzymes
Excretion
- Less than 1% of parent drug is excreted in the urine
- Approximately 80% of an oral dose is excreted as inactive metabolites in the urine
Interaction
- Extensively metabolized in the liver by CYP2C19 and CYP3A4
- No clinically relevant interactions with certain CYP enzymes
- Potential interference with CYP2C19
- No clinically significant interactions with specific drugs
Contraindications
- Contraindicated in patients with known hypersensitivity to any of the formulation
SideEffects
- Headache
- Diarrhoea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
PregnancyAndLactation
- No adequate and well-controlled studies in pregnant women
- Animal studies show no teratogenic effects
- Excretion in milk not studied
- Breast-feeding should be discontinued if essential
PrecautionsAndWarnings
- Symptomatic response does not preclude the presence of gastric malignancy
- Instructions for patients regarding capsule administration and antacid use
SpecialPopulations
- PediatricUse:
- Safety and effectiveness not established in pediatric patients
- GeriatricUse:
- No overall differences in safety and efficacy observed between the elderly and younger individuals
- HepaticInsufficiency:
- No dosage adjustment recommended for mild to moderate hepatic insufficiency
- Dose should not exceed 20 mg daily in severe hepatic insufficiency
- RenalInsufficiency:
- Pharmacokinetics not expected to be altered in patients with renal impairment
OverdoseEffects
- Toxic in rats at a dose 103 times the human dose on a body surface area basis
- Signs of acute toxicity include reduced motor activity, respiratory changes, tremor, and convulsions
- No specific antidote known
- Symptomatic and supportive treatment recommended
StorageConditions
- Store at a temperature not exceeding 30°C in a dry place
- Protect from light and moisture
- Keep out of reach of children
ChemicalStructure
- MolecularFormula: C17H19N3O3S
- ChemicalStructure: Image of chemical structure provided
CommonQuestions
- WhatIsIt: Esopin 20 mg Tablet is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach
- Uses:
- Treats GERD, ulcers, and conditions involving excessive stomach acid
- SideEffects:
- Headaches
- Diarrhea
- Nausea
- Gas
- Stomach pain
- Constipation
- Dry mouth
- PregnancyAndBreastfeeding: No side-effects but should be discussed with a doctor
- OnsetOfAction: Usually starts within a few hours of taking
- QuickTips:
- Avoid eating late at night or before bedtime
- Inform your doctor in case of persistent stomach issues or side effects
- Long-term use can impact bone health and mineral levels, consult your doctor
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