Miganil 5 mg (Tablet)
Unit Price: ৳ 3.00 (5 x 10: ৳ 150.00)
Strip Price: ৳ 30.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Flunarizine |
| Company | Globe pharmaceuticals ltd |
| Also available as |
Title
- Miganil
Categories
- Prophylactic Migraine Preparations
Description
- Flunarizine derivative of cinnarizine
- Selective calcium channel antagonist
- Prevents cellular calcium overload
- Antihistaminic and sedative properties
- Binds at an affinity of 99% to plasma protein
- Dosage varies with age and conditions
- Interacts with oral contraceptives, Carbamazepine, and Phenytoin
- Contraindicated in hypersensitivity to Flunarizine, depressive illness, pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
- Adverse effects include drowsiness, fatigue, weight gain, increased appetite, depression, extrapyramidal symptoms
- Safety not established in pregnancy and lactation
- May cause drowsiness, caution against driving or hazardous tasks, not suitable for aborting a migraine attack
- Considerations for elderly predisposed patients
- Miscellaneous prophylactic migraine preparations
- Storage temperature below 30°C, away from light & moisture, keep out of reach of children
Indications
- Prophylaxis of classic or common migraine with or without aura
- Symptomatic treatment of vestibular vertigo
- Peripheral Vascular Disease (PVD)
- Motion sickness
- Refractory epilepsy resistant to conventional antiepileptic therapy
Pharmacology
- Selective calcium channel antagonist
- Reduces excessive transmembrane influx of calcium
- Prevents cellular calcium overload
- Has antihistaminic and sedative properties
- Binds at an affinity of 99% to plasma protein
Dosage & administration
- Starting dose varies with age
- Maintenance treatment may be needed after initial treatment
- Peripheral Vascular Disease: 10 mg twice daily, up to 30 mg per day if required
- Vertigo & motion sickness: 10-20 mg daily for adults, 5 mg daily for children
- Epileptic seizure: 15-20 mg daily in adults, 5 to 10 mg daily for children as an add-on therapy
Interaction
- Galactorrhoea reported in few women on oral contraceptives
- Hepatic enzyme inducers may increase metabolism and require an increase in dosage
Contraindications
- Hypersensitivity to Flunarizine
- History of depressive illness
- Pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
Side effects
- Drowsiness
- Fatigue
- Weight gain
- Increased appetite
- Depression
- Extrapyramidal symptoms
- Heartburn
- Nausea
- Gastralgia
- Insomnia
- Anxiety
- Galactorrhoea
- Dry mouth
- Muscle ache
- Skin rash
Pregnancy & lactation
- Safety not established
Precautions & warnings
- May lead to drowsiness
- Aggravated by simultaneous intake of alcohol or other CNS depressants
- Caution against driving or performing hazardous tasks
- Not suitable for aborting a migraine attack
- May give rise to extrapyramidal and depressive symptoms
- Reveals Parkinsonism especially in predisposed patients
Therapeutic class
- Miscellaneous prophylactic migraine preparations
Storage conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children