Miganil 10 mg (Tablet)
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Flunarizine |
| Company | Globe pharmaceuticals ltd |
| Also available as |
Indications
- Prophylaxis of classic (with aura) migraine
- Prophylaxis of common (without aura) migraine
- Symptomatic treatment of vestibular vertigo
- Symptomatic treatment of peripheral vascular disease (PVD)
- Symptomatic treatment of motion sickness
- Symptomatic treatment of refractory epilepsy resistant to conventional antiepileptic therapy
Pharmacology
- Flunarizine is a difluorinated derivative of cinnarizine
- Selective calcium channel antagonist
- Prevents cellular calcium overload
- Has antihistaminic and sedative properties
- Binds at an affinity of 99% to plasma protein
Dosage & Administration
- Starting dose: 10 mg at night in patients less than 65 years of age
- Starting dose: 5 mg daily in patients older than 65 years
- Maintenance treatment should be interrupted after 6 months
- Peripheral Vascular disease: 10 mg twice daily, up to 30 mg per day if required
- Vertigo & motion sickness: 10-20 mg daily for adults
- Vertigo & motion sickness: 5 mg daily for children (>40 kg)
- Epileptic seizure: 15-20 mg daily in adults
- Epileptic seizure: 5-10 mg daily for children as add-on therapy
Interaction
- Galactorrhoea reported in few women on oral contraceptives within the first two months of Miganil treatment
- Hepatic enzyme inducers such as Carbamazepine and Phenytoin may interact with Miganil
Contraindications
- Hypersensitivity to Flunarizine
- Contra-indicated in patients with a history of depressive illness
- Contra-indicated in patients with pre-existing symptoms of Parkinson's disease or other extrapyramidal disorders
Side Effects
- Drowsiness and/or fatigue
- Weight gain and/or increased appetite
- Adverse experiences reported during chronic treatment with Miganil: depression, extrapyramidal symptoms, heartburn, nausea, gastralgia, insomnia, anxiety, dry mouth, muscle ache, skin rash
Pregnancy & Lactation
- Safety in pregnancy and lactation has not been established
Precautions & Warnings
- May lead to drowsiness aggravated by alcohol or other CNS depressants
- Not suited for aborting a migraine attack
- Should be used with caution in predisposed patients such as the elderly
Therapeutic Class
- Miscellaneous prophylactic migraine preparations
Storage Conditions
- Keep below 30°C
- Away from light & moisture
- Keep out of the reach of children