Esoral 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 6.00 (8 x 14: ৳ 672.00)
Strip Price: ৳ 84.00

Medicine Details

Category Details
Generic Esomeprazole
Company Eskayef pharmaceuticals ltd
Also available as
Esoral 40 mg tablet Esoral 20 mg capsule Esoral 40 mg capsule Esoral 40 mg injection Esoral 20 mg powder

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment for Zollinger-Ellison Syndrome
  • Relief from acid-related Dyspepsia
  • Treatment for Duodenal and Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor (S-isomer of omeprazole)
  • Better acid control than racemic proton pump inhibitors
  • Absorption occurs at approximately 1.5 hours after oral administration
  • Systemic bioavailability is approximately 90%
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Plasma elimination half-life of approximately 1–1.5 hours

Dosage

  • Oral dosage form for healing of erosive esophagitis: 20 mg or 40 mg once daily for 4-8 weeks
  • Oral dosage form for symptomatic GERD: 20 mg once daily for 4 weeks
  • Oral dosage form for duodenal and gastric ulcer: 20 mg once daily for 2-8 weeks
  • IV Injection or IV infusion dosage for adults with GERD with erosive esophagitis: 20 mg or 40 mg once daily

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be stirred well and consumed within 30 minutes
  • IV Injection should be administered intravenously over a period of at least 3 minutes

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Does not have clinically significant interactions with certain drugs metabolized by specific CYP enzymes
  • May potentially interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Common adverse events include headache, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies revealed no teratogenic effects
  • Excretion in milk not studied, breastfeeding should be discontinued if use is essential

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Capsules should be taken at least one hour before meals
  • Antacids may be used while taking the drug

Use in Special Populations

  • Safety and effectiveness in paediatric patients have not been established
  • No overall differences in safety and efficacy observed between elderly and younger individuals

Overdose Effects

  • A single oral dose at 510 mg/kg has been lethal to rats
  • Signs of acute toxicity include reduced motor activity, changes in respiratory frequency, tremor, and convulsions

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image provided in the source

Common Questions about Esoral 20 mg Tablet

  • Used to treat gastroesophageal reflux disease (GERD), ulcers, and conditions with excessive stomach acid production
  • Common side effects include headaches, diarrhea, nausea, and stomach pain
  • Pregnant or breastfeeding individuals should consult a doctor before use

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