Esoral 40 mg (Capsule (Enteric Coated))

Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Esomeprazole
Company Eskayef pharmaceuticals ltd
Also available as
Esoral 20 mg tablet Esoral 40 mg tablet Esoral 20 mg capsule Esoral 40 mg injection Esoral 20 mg powder

Title

  • Esoral 40 mg Capsule

Categories

  • Medicine
  • Health & Wellness

Description

  • A proton pump inhibitor used to relieve chronic heartburn symptoms, heal erosive esophagitis, control acid-related dyspepsia, treat duodenal and gastric ulcers, eradicate Helicobacter pylori infection, manage Zollinger-Ellison Syndrome, and relieve symptoms of GERD.

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Management of Zollinger-Ellison Syndrome
  • Treatment of acid-related dyspepsia
  • Treatment of duodenal and gastric ulcers

Pharmacology

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation
  • Absorption within 1.5 hours after oral administration
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Excreted as inactive metabolites in the urine and faeces

Dosage

  • Oral dosage form for healing of erosive esophagitis
  • Oral dosage form for symptomatic GERD
  • Oral dosage form for Helicobacter pylori eradication
  • Oral dosage form for Zollinger-Ellison Syndrome
  • Oral dosage form for acid-related dyspepsia
  • Oral dosage form for duodenal and gastric ulcer
  • IV Injection for GERD with erosive esophagitis in adult patients
  • IV Injection for risk reduction of rebleeding of gastric or duodenal ulcers in adult patients
  • IV Injection for pediatric patients based on body weight
  • IV Infusion for pediatric patients based on body weight

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension should be mixed with water and consumed within 30 minutes
  • IV Injection should be prepared using 0.9% Sodium Chloride and administered intravenously over a period of at least 3 minutes

Interaction

  • Metabolized in the liver by CYP2C19 and CYP3A4
  • Unlikely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1 and 3A4
  • No clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin or amoxicillin
  • Potential interference with drugs where gastric pH is an important determinant of bioavailability
  • Increases plasma levels of certain drugs in combination therapy with clarithromycin

Contraindications

  • Known hypersensitivity to any of the formulation

Side effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy and lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Excretion in milk not studied
  • Breast-feeding should be discontinued if use is essential

Precautions and warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Capsules should be taken at least one hour before meals
  • Pellets inside capsules should not be chewed or crushed
  • Antacids may be used while taking Esoral

Use in special populations

  • Safety and effectiveness in paediatric patients not established
  • No overall differences in safety and efficacy observed between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose effects

  • Signs of acute toxicity in animals
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure: Image available

Commonly asked questions

  • Definition and uses of Esoral 40 mg Capsule
  • Side effects of Esoral 40 mg Capsule
  • Safety during pregnancy and breastfeeding
  • Time for Esoral 40 mg Capsule to work
  • Quick tips for using Esoral 40 mg Capsule

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