Mudibak 0.5 mg+10 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Fluphenazine nortriptyline |
| Company | Rephco pharmaceuticals ltd |
Indications
- Mild to moderate mixed anxiety/depression
- Emotional disturbance
- Sleep disorder
- Gastric problems
Description
Fluphenazine is a tranquilizer of the phenothiazine type. Nortriptyline is a tricyclic antidepressant having less sedative action. Mudibak has been found as effective preparation for the patients suffering from 'anxiety' or 'depression' or both and helps to restore functional ability without developing any drug dependence.
Pharmacology
- Nortriptyline hydrochloride: Tricyclic antidepressant. Inhibits the uptake of norepinephrine and serotonin at nerve terminals.
- Fluphenazine: Tranquilizer of the phenothiazine type with piperazine side chain. Acts as a neuroleptic drug with main therapeutic effect believed to reside in potent dopamine (specially D2) receptor antagonism.
Dosage & Administration
Adults: One tablet 2 to 3 times daily.
Interaction
Interactions with barbiturates, alcohol, and narcotic drugs may occur, so central depressants should be administered with caution.
Contraindications
- History of gradual epilepsy or organic brain damage
- Blood dyscrasia
- Severe cardiac insufficiency
- Renal or liver damage
- Patients taking monoamine oxidase inhibitor (MAOI)
- Younger children
- Hypersensitivity to any component of the preparation
Side Effects
Tardive dyskinesias, blood dyscrasia, malignant neuroleptic syndrome, sudden death, agranulocytosis
Pregnancy & Lactation
Safety in human pregnancy not established. Not recommended during lactation
Precautions & Warnings
Precautions should be taken in patients with glaucoma, prostate enlargement, cardiac failure, myocardial infarction, and concurrent administration with CNS depressants. The drug may impair alertness and abilities to drive a car or operate machinery.
Therapeutic Class
Combined anxiolytics & anti-depressant drugs
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.