Esotac 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.75 (6 x 10: ৳ 345.00)
Strip Price: ৳ 57.50

Medicine Details

Category Details
Generic Esomeprazole
Company Navana pharmaceuticals ltd
Also available as
Esotac 40 mg tablet Esotac 20 mg capsule Esotac 40 mg injection Esotac 40 mg capsule

Title

Esotac 20 mg Tablet

Categories

  • Medicine
  • Gastric Health
  • Acid Reducer
  • Proton Pump Inhibitor
  • Gastrointestinal Medication

Description

Esotac 20 mg Tablet is a proton pump inhibitor used to relieve chronic heartburn symptoms, heal erosive esophagitis, maintain healing, eradicate Helicobacter pylori infection, and treat Zollinger-Ellison Syndrome, acid-related dyspepsia, duodenal and gastric ulcers.

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Treatment of Zollinger-Ellison Syndrome
  • Management of Acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Mode of Action: Suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Absorption: Enteric-coated pellet formulation, peak plasma levels occur at approximately 1.5 hours
  • Distribution: 97% bound to plasma proteins, constant over the concentration range of 2-20 mmol/L
  • Metabolism: Extensively metabolized in the liver by the CYP enzyme system
  • Excretion: Plasma elimination half-life is approximately 1-1.5 hours, less than 1% excreted in the urine

Dosage

  • Oral Dosage:
    • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
    • Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily (Clinical studies did not extend beyond 6 months)
    • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
  • IV Injection or IV Infusion:
    • 20 mg or 40 mg once daily for adults
    • 10 mg-20 mg once daily for pediatric patients

Administration

  • Tablet or Capsule: Should be swallowed whole and taken one hour before a meal
  • Oral Suspension: Contents of the packet should be mixed with water and consumed within 30 minutes
  • IV Injection: Prepared solution must be used within 12 hours of preparation and can be exposed to normal indoor lighting at a maximum of 30°C

Interactions

  • Metabolism: Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Inhibition: Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • Combination Therapy: Shown no clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin

Contraindications

Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • Pregnancy: No adequate and well-controlled studies in pregnant women
  • Breastfeeding: Excretion in milk not studied, breastfeeding should be discontinued if use is essential

Precautions & Warnings

  • General: Symptomatic response does not preclude the presence of gastric malignancy
  • Patients Information: Capsules should be taken at least one hour before meals, antacids may be used while taking Esotac

Use in Special Populations

  • Paediatric Use: Safety and effectiveness not established
  • Geriatric Use: No overall differences in safety and efficacy observed between the elderly and younger individuals
  • Hepatic Insufficiency: No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Renal Insufficiency: Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Signs: Reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions
  • Treatment: Symptomatic and supportive, no specific antidote known

Storage Conditions

Store at a temperature not exceeding 30°C in a dry place, protect from light and moisture, keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Commonly Asked Questions

  • Q1: What is Esotac 20 mg Tablet?
  • A1: Proton pump inhibitor used to reduce stomach acid
  • Q2: What is Esotac 20 mg Tablet used for?
  • A2: Relieve heartburn, heal erosive esophagitis, prevent recurrence
  • Q3: What are the side effects of Esotac 20 mg Tablet?
  • A3: Headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth
  • Q4: Can I take Esotac 20 mg Tablet if I am pregnant or breastfeeding?
  • A4: No adequate studies, talk to a doctor about risks and benefits
  • Q5: How long does it take for Esotac 20 mg Tablet to work?
  • A5: Usually starts to work within a few hours

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