Esotac 20 mg (Tablet (Enteric Coated))
Unit Price: ৳ 5.75 (6 x 10: ৳ 345.00)
Strip Price: ৳ 57.50
Medicine Details
Category | Details |
---|---|
Generic | Esomeprazole |
Company | Navana pharmaceuticals ltd |
Also available as |
Title
Esotac 20 mg Tablet
Categories
- Medicine
- Gastric Health
- Acid Reducer
- Proton Pump Inhibitor
- Gastrointestinal Medication
Description
Esotac 20 mg Tablet is a proton pump inhibitor used to relieve chronic heartburn symptoms, heal erosive esophagitis, maintain healing, eradicate Helicobacter pylori infection, and treat Zollinger-Ellison Syndrome, acid-related dyspepsia, duodenal and gastric ulcers.
Indications
- Relief from chronic heartburn symptoms
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
- Treatment of Zollinger-Ellison Syndrome
- Management of Acid-related Dyspepsia
- Treatment of Duodenal & Gastric ulcer
Pharmacology
- Mode of Action: Suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell
- Absorption: Enteric-coated pellet formulation, peak plasma levels occur at approximately 1.5 hours
- Distribution: 97% bound to plasma proteins, constant over the concentration range of 2-20 mmol/L
- Metabolism: Extensively metabolized in the liver by the CYP enzyme system
- Excretion: Plasma elimination half-life is approximately 1-1.5 hours, less than 1% excreted in the urine
Dosage
- Oral Dosage:
- Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
- Maintenance of Healing of Erosive Esophagitis: 20 mg Once Daily (Clinical studies did not extend beyond 6 months)
- Symptomatic GERD: 20 mg Once Daily for 4 Weeks
- IV Injection or IV Infusion:
- 20 mg or 40 mg once daily for adults
- 10 mg-20 mg once daily for pediatric patients
Administration
- Tablet or Capsule: Should be swallowed whole and taken one hour before a meal
- Oral Suspension: Contents of the packet should be mixed with water and consumed within 30 minutes
- IV Injection: Prepared solution must be used within 12 hours of preparation and can be exposed to normal indoor lighting at a maximum of 30°C
Interactions
- Metabolism: Extensively metabolized in the liver by CYP2C19 and CYP3A4
- Inhibition: Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
- Combination Therapy: Shown no clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin
Contraindications
Contraindicated in patients with known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- Pregnancy: No adequate and well-controlled studies in pregnant women
- Breastfeeding: Excretion in milk not studied, breastfeeding should be discontinued if use is essential
Precautions & Warnings
- General: Symptomatic response does not preclude the presence of gastric malignancy
- Patients Information: Capsules should be taken at least one hour before meals, antacids may be used while taking Esotac
Use in Special Populations
- Paediatric Use: Safety and effectiveness not established
- Geriatric Use: No overall differences in safety and efficacy observed between the elderly and younger individuals
- Hepatic Insufficiency: No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
- Renal Insufficiency: Pharmacokinetics not expected to be altered in patients with renal impairment
Overdose Effects
- Signs: Reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions
- Treatment: Symptomatic and supportive, no specific antidote known
Storage Conditions
Store at a temperature not exceeding 30°C in a dry place, protect from light and moisture, keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg
Commonly Asked Questions
- Q1: What is Esotac 20 mg Tablet?
- A1: Proton pump inhibitor used to reduce stomach acid
- Q2: What is Esotac 20 mg Tablet used for?
- A2: Relieve heartburn, heal erosive esophagitis, prevent recurrence
- Q3: What are the side effects of Esotac 20 mg Tablet?
- A3: Headache, diarrhea, nausea, flatulence, abdominal pain, constipation, dry mouth
- Q4: Can I take Esotac 20 mg Tablet if I am pregnant or breastfeeding?
- A4: No adequate studies, talk to a doctor about risks and benefits
- Q5: How long does it take for Esotac 20 mg Tablet to work?
- A5: Usually starts to work within a few hours
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