Flumetol 50 mcg+250 mcg (Inhalation Capsule)

Indications

• Regular treatment of asthma
• Combination product
• Inhaled corticosteroid therapy
• Asthma control
• Improving lung function
• Preventing exacerbations
• for patients not adequately controlled with inhaled corticosteroids
• for patients already adequately controlled on both inhaled corticosteroid and long-acting β2-agonist

Pharmacology

• Selective long-acting beta-2 agonist
• Corticosteroid with mainly glucocorticoid activity
• Topical effect on the lungs
• Protects against symptoms
• Improves lung function
• More convenient regime for patients on concurrent β-agonist and inhaled corticosteroid therapy

Dosage

• Adult dosage
• Adolescent dosage
• Children dosage
• Inhaler dosage
• Inhalation capsule dosage
• Maxhaler dosage
• Prescribed doses based on asthma severity

Administration

• Instructions for using Inhaler
• Cleaning Inhaler instructions
• Proper usage to prevent asthma attacks
• Mirror technique check
• Rinsing mouth after each treatment

Interaction

• Avoidance of non-selective β-blockers
• Avoidance of selective β-blockers in patients with asthma
• Care when co-administering strong CYP3A4 inhibitors

Contraindications

• Hypersensitivity to salmeterol xinafoate or fluticasone propionate
• Contraindicated in primary treatment of status asthmaticus or acute episodes of asthma

Side Effects

• Tremor
• Subjective palpitations
• Headache
• Cardiac arrhythmia
• Arthralgia
• Hypersensitivity reactions
• Rash
• Oedema
• Angioedema
• Oropharyngeal irritation
• Muscle cramps
• Hoarseness
• Candidiasis
• Cutaneous hypersensitivity reactions
• Facial and oropharyngeal oedema

Pregnancy & Lactation

• Consideration of benefit-risk ratio
• Insufficient experience in human pregnancy
• Reproductive toxicity studies in animals
• Insufficient experience in human lactation
• Low concentrations in human breast milk
• Studies in lactating animals

Precautions & Warnings

• Initiation in stable asthma patients
• Not for relief of acute symptoms
• Paradoxical Bronchospasm
• Increase in pneumonia reporting in COPD patients
• Potential systemic effects of corticosteroids
• Review & titration of inhaled corticosteroid dose

Use in Special Populations

• Potential reduction in growth velocity in paediatric patients

Overdose Effects

• Signs and symptoms of Salmeterol overdose
• Signs of Fluticasone Propionate overdose
• Temporary suppression of adrenal function
• Chronic overdose consequences
• Monitoring of adrenal reserve

Therapeutic Class

• Long-acting selective β-adrenoceptor stimulants
• Respiratory corticosteroids

Storage Conditions

• Pressurised canister
• Avoid puncture, break, or incineration
• Storage below 30°C
• Keep away from eyes and children

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