Protide (25 mcg+125 mcg)/puff (Inhaler)

Indications

• Regular treatment of asthma
• Combination product (long-acting β2-agonist and inhaled corticosteroid) is appropriate
• Patients not adequately controlled with inhaled corticosteroids
• Patients already adequately controlled on both inhaled corticosteroid and long-acting β2-agonist

Pharmacology

• Selective, long-acting beta-2 agonist for asthma
• Corticosteroid with mainly glucocorticoid activity for improving lung function

Dosage

• Different dosages for adults, adolescents, and children
• Inhalation capsule for asthma and COPD
• Maxhaler for asthma and COPD
• Daily use for optimum benefit
• No need to adjust the dose in elderly patients or in those with renal impairment

Administration

• Correct and regular use to prevent or lessen the severity of asthma attacks
• Steps to use inhaler effectively
• Instructions for cleaning inhaler

Interaction

• Avoid non-selective and selective β-blockers in patients with asthma
• Care when co-administering strong CYP3A4 inhibitors

Contraindications

• Contraindicated in patients with hypersensitivity to salmeterol xinafoate or fluticasone propionate
• Contraindicated in primary treatment of status asthmaticus or other acute episodes of asthma

Side Effects

• Pharmacological side effects of beta-2-agonist treatment
• Adverse events associated with Salmeterol or Fluticasone Propionate

Pregnancy & Lactation

• Consideration during pregnancy and lactation if benefit outweighs risk
• Insufficient experience of use in human pregnancy and lactation

Precautions & Warnings

• Not for relief of acute symptoms
• Serious asthma-related adverse events may occur
• Vigilance for pneumonia in patients with COPD
• Possible systemic effects of inhaled corticosteroid

Use in Special Populations

• Reduction in growth velocity in paediatric patients

Overdose Effects

• Signs and symptoms of Salmeterol overdose
• Temporary suppression of adrenal function with Fluticasone Propionate overdose

Therapeutic Class

• Long-acting selective β-adrenoceptor stimulants
• Respiratory corticosteroids

Storage Conditions

• Pressurised canister, do not puncture, break or incinerate
• Avoid storage in direct sunlight or heat

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