Esoz 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Esomeprazole
Company Astra biopharmaceuticals ltd
Also available as
Esoz 40 mg capsule Esoz 20 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment for Zollinger-Ellison Syndrome
  • Management of acid-related Dyspepsia
  • Treatment for Duodenal and Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase
  • Enteric-coated pellet formulation
  • Peak plasma levels occur at approximately 1.5 hours after oral administration
  • Extensively metabolized in the liver
  • Plasma protein binding is constant over the concentration range of 2-20 mmol/L

Dosage

  • Oral dosage form
  • IV Injection or IV infusion
  • Specific dosages for healing, maintenance, symptomatic GERD, H. pylori eradication, Zollinger-Ellison Syndrome, Dyspepsia, Duodenal and Gastric ulcer
  • Different dosages for adult and pediatric patients
  • IV administration for adults and pediatric patients
  • Dosage for risk reduction of rebleeding of Gastric or Duodenal Ulcers

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension instructions
  • IV Injection preparation and administration

Interaction

  • Metabolized by CYP2C19 and CYP3A4
  • Inhibition of CYP2C19 by Esoz
  • Interference with absorption of drugs based on gastric pH
  • No clinically significant interactions with certain drugs
  • Plasma level increases with combination therapy of clarithromycin

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Excretion in milk not studied
  • Breast-feeding discontinuation if use is essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Specific administration instructions for patients

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy between the elderly and younger individuals
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • Lethal effects observed in animal studies
  • No specific antidote known
  • Symptomatic and supportive treatment recommended

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular formula: C17H19N3O3S

Common Questions about Esoz 20 mg Tablet

  • Use as a proton pump inhibitor to reduce stomach acid production
  • Treats GERD, ulcers, and conditions involving excessive stomach acid
  • Common side effects include headaches, diarrhea, nausea, and stomach pain
  • No significant side effects observed during long-term use

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