Esoz 20 mg (Tablet (Enteric Coated))
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Esomeprazole |
| Company | Astra biopharmaceuticals ltd |
| Also available as |
Indications
- Relief from chronic heartburn symptoms
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection
- Treatment for Zollinger-Ellison Syndrome
- Management of acid-related Dyspepsia
- Treatment for Duodenal and Gastric ulcer
Pharmacology
- Proton pump inhibitor
- Suppression of gastric acid secretion
- Specific inhibition of the H+/K+-ATPase
- Enteric-coated pellet formulation
- Peak plasma levels occur at approximately 1.5 hours after oral administration
- Extensively metabolized in the liver
- Plasma protein binding is constant over the concentration range of 2-20 mmol/L
Dosage
- Oral dosage form
- IV Injection or IV infusion
- Specific dosages for healing, maintenance, symptomatic GERD, H. pylori eradication, Zollinger-Ellison Syndrome, Dyspepsia, Duodenal and Gastric ulcer
- Different dosages for adult and pediatric patients
- IV administration for adults and pediatric patients
- Dosage for risk reduction of rebleeding of Gastric or Duodenal Ulcers
Administration
- Tablet or capsule should be swallowed whole and taken one hour before a meal
- Oral Suspension instructions
- IV Injection preparation and administration
Interaction
- Metabolized by CYP2C19 and CYP3A4
- Inhibition of CYP2C19 by Esoz
- Interference with absorption of drugs based on gastric pH
- No clinically significant interactions with certain drugs
- Plasma level increases with combination therapy of clarithromycin
Contraindications
- Known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- No teratogenic effects in animal studies
- Excretion in milk not studied
- Breast-feeding discontinuation if use is essential
Precautions & Warnings
- Symptomatic response does not preclude the presence of gastric malignancy
- Specific administration instructions for patients
Use in Special Populations
- Safety and effectiveness in pediatric patients not established
- No overall differences in safety and efficacy between the elderly and younger individuals
- No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
- Pharmacokinetics not expected to be altered in patients with renal impairment
Overdose Effects
- Lethal effects observed in animal studies
- No specific antidote known
- Symptomatic and supportive treatment recommended
Storage Conditions
- Store at a temperature not exceeding 30°C
- Protect from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular formula: C17H19N3O3S
Common Questions about Esoz 20 mg Tablet
- Use as a proton pump inhibitor to reduce stomach acid production
- Treats GERD, ulcers, and conditions involving excessive stomach acid
- Common side effects include headaches, diarrhea, nausea, and stomach pain
- No significant side effects observed during long-term use