Esru 20 mg (Tablet (Enteric Coated))
Unit Price: ৳ 4.00 (5 x 10: ৳ 200.00)
Strip Price: ৳ 40.00
Medicine Details
Category | Details |
---|---|
Generic | Esomeprazole |
Company | Doctors chemical works ltd |
Indications
- Relief from chronic heartburn symptoms and other symptoms associated with GERD
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
- Zollinger-Ellison Syndrome
- Acid related Dyspepsia
- Duodenal & Gastric ulcer
Pharmacology
- Proton pump inhibitor
- Suppresses gastric acid secretion
- Specific inhibition of the H+/K+-ATPase
- Better acid control than racemic proton pump inhibitors
- Enteric-coated pellet formulation
- Absorption peak at approximately 1.5 hours
- Metabolized in the liver by cytochrome P450 enzyme system
- Extensively metabolized in the liver
- Plasma protein binding is constant over the concentration range
- Plasma elimination half-life is approximately 1–1.5 hours
Dosage
- Oral dosage form
- Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
- Symptomatic GERD: 20 mg Once Daily for 4 Weeks
- Helicobacter Pylori eradication: Triple Therapy for 10 days
- IV Injection for adult and pediatric patients
- Risk reduction of rebleeding of Gastric or Duodenal Ulcers following therapeutic endoscopy in adults
Administration
- Tablet or capsule should be swallowed whole and taken one hour before a meal
- Oral Suspension and IV Injection instructions
Interaction
- Extensively metabolized in the liver by CYP2C19 and CYP3A4
- No clinically relevant interactions with drugs metabolized by CYP enzymes
- Potential interference with CYP2C19
- Inhibition of gastric acid secretion may interfere with drug absorption
Contraindications
- Known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- Animal studies have revealed no teratogenic effects
- Excretion of esomeprazole in milk has not been studied
- Breast-feeding should be discontinued if the use of esomeprazole is considered essential
Precautions & Warnings
- Symptomatic response to therapy does not preclude the presence of gastric malignancy
- Instructions for patients
- Use in Special Populations: Paediatric, Geriatric, Hepatic Insufficiency, Renal Insufficiency
Overdose Effects
- Acute toxicity signs in rats
- No specific antidote known
- Symptomatic and supportive treatment is recommended
Storage Conditions
- Store at a temperature not exceeding 30°C in a dry place
- Protect from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
- Chemical Structure
Common Questions
- What is Esru 20 mg Tablet?
- What is Esru 20 mg Tablet used for?
- What are the side effects of Esru 20 mg Tablet?
- Pregnancy and breastfeeding concerns
- Duration for Esru 20 mg Tablet to work
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