Exium 40 mg (Capsule (Enteric Coated))
Unit Price: ৳ 12.00 (6 x 10: ৳ 720.00)
Strip Price: ৳ 120.00
Medicine Details
Category | Details |
---|---|
Generic | Esomeprazole |
Company | Radiant pharmaceuticals ltd |
Also available as |
Title
- Exium 40 mg Capsule
Categories
- Medicine
- Gastrointestinal Health
- Pharmaceutical
Description
- Exium 40 mg Capsule is a proton pump inhibitor (PPI) used to treat gastroesophageal reflux disease (GERD), ulcers, and symptoms associated with excessive stomach acid.
Indications
- Relief from chronic heartburn symptoms
- Healing of erosive esophagitis
- Maintenance of healing of erosive esophagitis
- Eradication of Helicobacter pylori infection
- Treatment of Zollinger-Ellison Syndrome
- Management of acid related Dyspepsia
- Treatment of Duodenal & Gastric ulcers
Mode of Action
- Suppression of gastric acid secretion by inhibition of the H+/K+-ATPase
- First single optical isomer of proton pump inhibitor
- Better acid control than racemic proton pump inhibitors
- Absorption peak plasma levels occur at approximately 1.5 hours after oral administration
Dosage Forms
- Oral capsules
- IV Injection or IV infusion
Dosage Instructions
- 20 mg or 40 mg Once Daily for 4-8 Weeks for healing of erosive esophagitis
- 20 mg Once Daily for maintenance of healing of erosive esophagitis
- 20 mg Once Daily for symptomatic GERD for 4 Weeks
- 40 mg Once Daily for Helicobacter pylori eradication in combination therapy
- 20-80 mg Once Daily for Zollinger-Ellison Syndrome
- 20-40 mg Once Daily for acid-related Dyspepsia
- 20 mg Once Daily for Duodenal ulcer, 20-40 mg Once Daily for Gastric ulcer
- Dosage for IV Injection and IV infusion based on age and condition
Administration
- Tablet or capsule should be swallowed whole and taken one hour before a meal
- Oral suspension should be taken with water and administered through a nasogastric or gastric tube if necessary
- IV Injection should be administered intravenously over at least 3 minutes
Interaction
- Metabolized in the liver by CYP2C19 and CYP3A4
- No clinically relevant interactions with certain CYP enzymes
- Potential interference with CYP2C19 metabolism
- Minimal interaction with other drugs like phenytoin, warfarin, clarithromycin, and amoxicillin
Contraindications
- Known hypersensitivity to any of the formulation
Side Effects
- Headache
- Diarrhoea
- Nausea
- Flatulence
- Abdominal pain
- Constipation
- Dry mouth
Pregnancy & Lactation
- No adequate and well-controlled studies in pregnant women
- No data on excretion in milk
- Breast-feeding should be discontinued if essential
Precautions & Warnings
- Symptomatic response to therapy does not rule out presence of gastric malignancy
- Specific instructions for patients with swallowing difficulties
- Use of antacids alongside Exium
Use in Special Populations
- Safety and effectiveness in paediatric patients not established
- No overall differences in safety and efficacy between elderly and younger individuals
- No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
- No alteration in pharmacokinetics expected in patients with renal impairment
Overdose Effects
- Acute toxicity observed in animal studies at high doses
- No specific antidote known
- Symptomatic and supportive treatment recommended in case of overdose
Storage Conditions
- Store at a temperature not exceeding 30°C in a dry place
- Protect from light and moisture
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C17H19N3O3S
Commonly Asked Questions
- Multiple uses including treating GERD, ulcers, and preventing erosive esophagitis recurrence
- Common side effects like headaches, diarrhea, and nausea
- Pregnant or breastfeeding women should consult a doctor before use
- Fast onset of action usually within a few hours of ingestion
- Quick tips for taking Exium 40 mg Capsule
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