Gipid 1 mg (Tablet)

Unit Price: ৳ 4.00 (3 x 10: ৳ 120.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Glimepiride
Company Alco pharma ltd
Also available as
Gipid 2 mg tablet

Indications

  • Adjunct to diet and exercise for Type II diabetes mellitus
  • Combination use with metformin for glycaemic control
  • Combination use with insulin for hyperglycaemia control
  • Potential for hypoglycaemia with combined use of Gipid and insulin

Pharmacology

  • Sulfonylurea antidiabetic agent
  • Decreases blood glucose concentration
  • Stimulates insulin release from pancreatic beta cells
  • Improves beta cell sensitivity to glucose stimulus
  • Reduces basal hepatic glucose production
  • Increases peripheral tissue sensitivity to insulin
  • Enhances glucose uptake
  • Hypoglycaemic action persists for 24 hours

Dosage

  • Governed by desired blood sugar level
  • Lowest dose sufficient for metabolic control
  • Based on regular monitoring of glucose levels
  • Usual initial dose of 1 mg once daily
  • Gradual dose titration intervals of 1 to 2 weeks
  • Dose range in well-controlled diabetes: 1 to 4 mg daily
  • Timing and distribution decided by physician
  • Single daily dose before substantial breakfast or first main meal
  • Dose adjustment with improved diabetes control and changes in weight or lifestyle
  • Initial daily dose when switching from other oral antidiabetics: 1 mg

Administration

  • Tablet must be swallowed with sufficient liquid

Interaction

  • Potentiating drugs: ACE inhibitors, corticosteroids, fluconazole, MAO-inhibitors, etc.
  • Attenuating drugs: Barbiturates, diuretics, phenothiazines, thyroid hormones, etc.
  • Potential for masking warning symptoms of hypoglycaemic attack
  • Unpredictable interaction with acute and chronic alcohol intake

Contraindications

  • Not for insulin dependent (type I) diabetes mellitus
  • Not for diabetic ketoacidosis or diabetic coma
  • Hypersensitivity to Glimepiride, sulfonylureas, sulfonamides
  • Severe hepatic dysfunction, severe impairment of renal function, dialysis patients

Side Effects

  • Hypoglycaemia
  • Temporary visual impairment
  • Nausea, vomiting, diarrhea, abdominal pain
  • Urticaria, fall in blood pressure

Pregnancy & Lactation

  • Not to be taken during pregnancy; insulin changeover required
  • Breast milk feeding may harm the child; not to be taken by breastfeeding women

Precautions & Warnings

  • Increased risk of hypoglycaemia in initial weeks of treatment
  • Necessity for careful monitoring and dose adjustment
  • Prompt control of hypoglycaemia with immediate intake of carbohydrates

Overdose Effects

  • Hypoglycaemia in cases of overdosage
  • Mild symptoms treated with oral glucose and adjustments in drug dosage or meal patterns
  • Severe symptoms constituting medical emergencies requiring hospitalization
  • Treatment with rapid intravenous glucose injection

Therapeutic Class

  • Sulfonylureas

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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