iMAX 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.00 (6 x 10: ৳ 300.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Esomeprazole
Company Delta pharma ltd
Also available as
Imax 40 mg capsule

Title

  • iMAX 20 mg Capsule

Categories

  • Medicine
  • GERD Treatment
  • Proton Pump Inhibitor

Description

  • iMAX is indicated for relieving chronic heartburn symptoms and other symptoms associated with GERD, healing of erosive esophagitis, maintenance of healing of erosive esophagitis, eradication of Helicobacter pylori infection, Zollinger-Ellison Syndrome, acid-related Dyspepsia, duodenal ulcer, and gastric ulcer.

Dosage form

  • Oral tablet
  • Oral capsule
  • Oral suspension
  • IV Injection
  • IV Infusion

Dosage strength

  • 20 mg
  • 40 mg
  • 80 mg

Mode of action

  • Suppression of gastric acid secretion by specific inhibition of the H+/K+-ATPase in the gastric parietal cell
  • First single optical isomer of proton pump inhibitor, provides better acid control than racemic proton pump inhibitors

Absorption

  • Peak plasma levels (Cmax) occur at approximately 1.5 hours (Tmax)
  • Systemic bioavailability is approximately 90% compared to 64% after a single dose

Distribution

  • 97% bound to plasma proteins
  • Plasma protein binding is constant over the concentration range of 2-20 mmol/L
  • Apparent volume of distribution at steady state in healthy volunteers is approximately 16 L

Metabolism

  • Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Metabolites lack anti-secretory activity
  • Dependent on CYP2C19 isoenzyme and CYP3A4

Excretion

  • Plasma elimination half-life is approximately 1-1.5 hours
  • Less than 1% of parent drug is excreted in the urine

Combination therapy

  • Esomeprazole magnesium 40 mg once daily is given in combination with clarithromycin 500 mg twice daily and amoxicillin 1000 mg twice daily for 7 days

Contraindications

  • Known hypersensitivity to any of the formulation

Side effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy and lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Capsules should be taken at least one hour before meals

Special populations

  • No established safety and effectiveness in pediatric patients
  • No overall differences in safety and efficacy between the elderly and younger individuals

Overdose effects

  • Reduced motor activity
  • Changes in respiratory frequency
  • Tremor
  • Ataxia
  • Intermittent clonic convulsions

Storage conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical structure

  • Molecular Formula: C17H19N3O3S

Common questions

  • What is iMAX 20 mg Capsule?
  • What is iMAX 20 mg Capsule used for?
  • What are the side effects of iMAX 20 mg Capsule?
  • Can I take iMAX 20 mg Capsule if I am pregnant or breastfeeding?
  • How long does it take for iMAX 20 mg Capsule to work?
  • iMAX 20 mg Capsule is a well-tolerated medicine and provides relief for a long time
  • Avoid eating late at night or before bedtime

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral suspension should be taken with water and can be administered through a nasogastric or gastric tube
  • IV Injection: Solution for injection is prepared by adding 5 ml of 0.9% Sodium Chloride for intravenous injection into the vial containing the dry powder

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • No clinically relevant interactions with drugs metabolized by these CYP enzymes expected
  • May potentially interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability

Pediatric use

  • Safety and effectiveness in paediatric patients not established
  • Greater sensitivity of some older individuals cannot be ruled out

Renal insufficiency

  • Pharmacokinetics in patients with renal impairment not expected to be altered relative to healthy volunteers as less than 1% of iMAX is excreted unchanged in the urine

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