Nitrosol SR 2.6 mg (Tablet (Sustained Release))
Unit Price: ৳ 5.00 (3 x 10: ৳ 150.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Nitroglycerin tablet |
| Company | Beximco pharmaceuticals ltd |
Indications
- Prophylaxis of angina pectoris
Pharmacology
- Relaxation of vascular smooth muscle
- Vasodilator effect on peripheral arteries and veins
- Decreases venous return to the heart
- Reduces left ventricular end-diastolic pressure
- Reduces systemic vascular resistance and arterial pressure
Dosage & Administration
- Dosage adjustment according to individual patient
- One Nitroglycerin 2.6 mg sustained released tablet or capsule in morning and evening
- Empty stomach intake
Interaction
- May increase antihypertensive properties of vasodilators, calcium antagonists, beta-adrenergic blockers
- Concomitant use with tricyclic antidepressants and alcohol may cause high blood pressure
- Concomitant use with phosphodiesterase type 5 (PDE5) inhibitors may cause fall in blood pressure
- Aspirin decreases clearance and enhances hemodynamic effects
- Reduces pharmacologic effects of heparin
- Increases bioavailability of dihydroergotamine
Contraindications
- Known hypersensitivity to nitroglycerin, organic nitrates, or nitrites
- Acute myocardial infarction
- Marked anaemia
- Head trauma
- Cerebral haemorrhage
- Closed angle glaucoma
Side Effects
- Headache at onset of treatment
- Tachycardia
- Postural hypotension and syncope
- Cyanosis
- Methaemoglobinaemia
Pregnancy & Lactation
- No evidence on safety in pregnancy and lactation
- Should only be administered if considered essential by physician
Precautions & Warnings
- Caution in patients predisposed to closed-angle glaucoma
- Abrupt discontinuation may lead to exacerbation of symptoms
- Long term treatment should be discontinued gradually over several days
- Particular attention during the early days of acute myocardial infarction
Overdose Effects
- Peripheral vasodilation with fall in blood pressure
- Reflex tachycardia
- Monitoring of cardiac function and general supportive measures
- Increased circulating plasma volume by substitution of fluid
- Administration of vasopressors in life-threatening situations
Therapeutic Class
- Coronary vasodilators
Storage Conditions
- Cool and dry place away from light and heat
- Keep out of the reach of children