Nexum 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.02 (6 x 10: ৳ 421.20)
Strip Price: ৳ 70.20

Medicine Details

Category Details
Generic Esomeprazole
Company Square pharmaceuticals plc
Also available as
Nexum 40 mg capsule Nexum 40 mg injection

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment for Zollinger-Ellison Syndrome
  • Management of acid-related Dyspepsia
  • Treatment for Duodenal and Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Specific inhibition of H+/K+-ATPase in gastric parietal cell
  • First single optical isomer of proton pump inhibitor
  • Better acid control than racemic proton pump inhibitors
  • Enteric-coated pellet formulation of esomeprazole magnesium
  • Peak plasma levels occur at approximately 1.5 hours
  • Distribution: 97% bound to plasma proteins
  • Metabolized in the liver by CYP enzyme system
  • Plasma elimination half-life of approximately 1-1.5 hours

Dosage

  • Oral dosage form
  • Healing of Erosive Esophagitis: 20mg or 40mg Once Daily for 4-8 Weeks
  • Symptomatic GERD: 20mg Once Daily for 4 Weeks
  • IV Injection: 20mg or 40mg once daily for adult patients
  • Maintenance of healing of erosive esophagitis: 20mg Once Daily
  • Treatment for Helicobacter pylori eradication: 40mg Once Daily for 10 days in combination therapy
  • Zollinger-Ellison Syndrome: 20-80mg once daily
  • Acid-related Dyspepsia: 20-40mg once daily for 2-4 weeks
  • Dosing in pediatric patients based on weight

Administration

  • Tablet or capsule to be swallowed whole
  • Oral suspension to be taken with water
  • IV Injection: must be administered intravenously over a period of at least 3 minutes

Interactions

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain CYP enzymes expected
  • Potential interference with absorption of drugs where gastric pH is important for bioavailability
  • Interaction with oral contraceptives, diazepam, phenytoin, or quinidine

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Frequently occurring adverse events include headaches, diarrhea, nausea, flatulence, abdominal pain, constipation, and dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • Excretion of esomeprazole in milk not studied

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric malignancy
  • Administration at least one hour before meals
  • Instruction for patients who have difficulty swallowing capsules

Use in Special Populations

  • Safety and effectiveness in pediatric patients not established
  • No overall differences in safety and efficacy for geriatric use
  • No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose Effects

  • No specific antidote known
  • Treatment should be symptomatic and supportive
  • Possibility of multiple drug ingestion should be considered

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Common Questions about Nexum 20 mg Capsule

  • Proton pump inhibitor that reduces stomach acid production
  • Used to treat gastroesophageal reflux disease, ulcers, and conditions involving excessive stomach acid
  • Common side effects include headaches, diarrhea, nausea, gas, stomach pain, constipation, and dry mouth

Related Brands