Progut 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00

Medicine Details

Category Details
Generic Esomeprazole
Company Popular pharmaceuticals ltd
Also available as
Progut 20 mg capsule Progut 40 mg capsule Progut 40 mg injection

Indications

  • Relief from chronic heartburn symptoms and other symptoms associated with GERD
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection in patients with duodenal ulcer disease
  • Zollinger-Ellison Syndrome
  • Acid related Dyspepsia
  • Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Suppression of gastric acid secretion
  • Inhibition of the H+/K+-ATPase in the gastric parietal cell
  • Enteric-coated pellet formulation
  • Metabolized in the liver by the cytochrome P450 (CYP) enzyme system

Dosage

  • Oral dosage form
  • IV Injection or IV infusion
  • Various dosages for different indications
  • Oral suspension and tablet/capsule administration instructions

Administration

  • Swallowed whole and taken one hour before a meal
  • Preparation of oral suspension
  • Preparation of IV injection solution

Interaction

  • Metabolized by CYP2C19 and CYP3A4
  • No clinically relevant interactions with certain drugs
  • Potential interference with CYP2C19 and gastric pH-dependent drug absorption

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies show no teratogenic effects
  • Excretion in milk not studied

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Administration instructions for patients
  • Use of antacids with Progut

Use in Special Populations

  • Safety and effectiveness in pediatric and geriatric patients
  • No dose adjustment for mild to moderate hepatic insufficiency
  • No expected alteration in pharmacokinetics in patients with renal impairment

Overdose Effects

  • Lethal dose in rats
  • Signs of acute toxicity
  • No specific antidote known

Storage Conditions

  • Store at a temperature not exceeding 30°C
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular formula C17H19N3O3S

Common Questions about Progut 20 mg Tablet

  • Multiple uses including treating GERD and ulcers
  • Common side effects
  • Pregnancy and breastfeeding considerations
  • Time to onset of action

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