Progut 20 mg (Capsule (Enteric Coated))

Indications

• Relief from chronic heartburn symptoms
• Healing of erosive esophagitis
• Maintenance of healing of erosive esophagitis
• Eradication of Helicobacter pylori infection
• Treatment of Zollinger-Ellison Syndrome
• Management of acid-related Dyspepsia
• Treatment of Duodenal and Gastric ulcer

Pharmacology

• Proton pump inhibitor
• Suppression of gastric acid secretion
• Inhibition of H+/K+-ATPase
• Better acid control
• Enteric-coated pellet formulation
• Peak plasma levels at approximately 1.5 hours
• Metabolized in the liver by CYP enzymes
• Extensive metabolism in the liver
• Plasma protein binding

Dosage

• 20 mg or 40 mg Once Daily for healing of erosive esophagitis
• 20 mg Once Daily for maintenance of healing of erosive esophagitis
• 20 mg Once Daily for symptomatic GERD
• Triple Therapy for Helicobacter pylori eradication
• 20-80 mg Once Daily for Zollinger-Ellison Syndrome
• 20-40 mg Once Daily for acid-related Dyspepsia
• 20 mg Once Daily for 2-4 weeks for Duodenal ulcer
• 20-40 mg Once Daily for 4-8 weeks for Gastric ulcer
• Dosage for IV Injection or IV infusion

Administration

• Swallowed whole and taken one hour before a meal for tablets or capsules
• Instructions for oral suspension
• Preparation of IV Injection solution
• Clear and colorless to very slightly yellow solution

Interaction

• Extensive metabolism in the liver by CYP2C19 and CYP3A4
• No clinically relevant interactions with certain CYP enzymes
• Potential interference with the absorption of certain drugs
• Co-administration with oral contraceptives, diazepam, phenytoin, or quinidine

Contraindications

• Known hypersensitivity to any of the formulation

Side Effects

• Headache
• Diarrhoea
• Nausea
• Flatulence
• Abdominal pain
• Constipation
• Dry mouth
• No significant difference in adverse events during maintenance treatment

Pregnancy & Lactation

• No adequate and well-controlled studies in pregnant women
• No teratogenic effects observed in animal studies
• Excretion of esomeprazole in milk not studied
• Discontinuation of breastfeeding if essential use of esomeprazole

Precautions & Warnings

• Symptomatic response does not preclude the presence of gastric malignancy
• Instructions for patients
• Use of antacids while taking Progut

Use in Special Populations

• Safety and effectiveness in paediatric patients not established
• No overall differences in safety and efficacy in elderly
• No dosage adjustment for patients with mild to moderate hepatic insufficiency
• No alteration of pharmacokinetics in patients with renal impairment

Overdose Effects

• Acute toxicity in animal studies
• No specific antidote known
• Expected to be extensively protein bound
• Symptomatic and supportive treatment recommended

Storage Conditions

• Temperature not exceeding 30°C
• Dry place
• Protection from light and moisture
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C17H19N3O3S

Common Questions about Progut 20 mg Capsule

• Usage as a proton pump inhibitor for reducing stomach acid production
• Multiple uses including treatment of GERD, ulcers and other conditions
• Common side effects and their occurrence
• Safety during pregnancy and breastfeeding
• Onset of action and quick tips for usage

Related Brands

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