Progut 40 mg/vial (IV Injection)

40 mg vial: ৳ 90.00

Medicine Details

Title

  • Progut 40 mg/vial Injection

Category

  • Gastric Medication

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Treatment of acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcers

Mode of Action

  • Proton pump inhibitor
  • Suppresses gastric acid secretion
  • Specific inhibition of the H+/K+-ATPase in the gastric parietal cell

Absorption

  • Peak plasma levels occur at approximately 1.5 hours after oral administration

Distribution

  • 97% bound to plasma proteins
  • Constant plasma protein binding over the concentration range

Metabolism

  • Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system

Excretion

  • Plasma elimination half-life of approximately 1–1.5 hours
  • Less than 1% excreted unchanged in the urine

Dosage Form

  • Tablet
  • Capsule
  • Oral Suspension
  • IV Injection
  • IV Infusion

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Suspension should be consumed within 30 minutes
  • IV Injection must be administrated intravenously over a period of at least 3 minutes

Interaction

  • Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
  • No clinically significant interactions with certain drugs

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • Animal studies have revealed no teratogenic effects
  • Excretion in milk not studied
  • Breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Patients should take capsules at least one hour before meals
  • Antacids may be used while taking Progut

Pediatric Use

  • Safety and effectiveness not established
  • Geriatric Use: No overall differences in safety and efficacy observed between elderly and younger individuals

Overdose Effects

  • Reduced motor activity
  • Changes in respiratory frequency
  • Tremor
  • Ataxia
  • Intermittent clonic convulsions
  • No specific antidote known
  • Treatment should be symptomatic and supportive

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

Commonly Asked Questions

  • Uses of Progut 40 mg/vial Injection
  • Side effects of Progut 40 mg/vial Injection
  • Pregnancy and breastfeeding related inquiries
  • Onset of Progut 40 mg/vial Injection's effect
  • Quick tips for using Progut 40 mg/vial Injection

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