Pronex 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 6.00 (4 x 14: ৳ 336.00)
Strip Price: ৳ 84.00

Medicine Details

Category Details
Generic Esomeprazole
Company Drug international ltd
Also available as
Pronex 40 mg tablet Pronex 40 mg injection Pronex 20 mg capsule Pronex 40 mg capsule

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcer

Pharmacology

  • Proton pump inhibitor
  • Specific inhibition of H+/K+-ATPase
  • Better acid control than racemic proton pump inhibitors
  • Absorption peak at 1.5 hours
  • Metabolized by cytochrome P450 enzyme system
  • Plasma elimination half-life of approximately 1-1.5 hours

Dosage

  • 20 mg or 40 mg once daily for healing of erosive esophagitis
  • 20 mg once daily for maintenance of healing of erosive esophagitis
  • 20 mg once daily for symptomatic GERD
  • Triple therapy for Helicobacter pylori eradication
  • 20-80 mg once daily for Zollinger-Ellison Syndrome
  • 20-40 mg once daily for acid-related Dyspepsia
  • 20 mg once daily for 2-4 weeks for Duodenal ulcer
  • 20-40 mg once daily for 4-8 weeks for Gastric ulcer
  • IV injection or infusion for various conditions and age groups

Administration

  • Tablet or capsule should be swallowed whole and taken one hour before a meal
  • Oral Suspension should be taken with water and administered through a nasogastric or gastric tube
  • IV Injection: Must be administered intravenously over a period of at least 3 minutes

Interaction

  • Extensive metabolism by CYP2C19 and CYP3A4
  • No clinically significant interactions with specific drugs
  • Potential interference with CYP2C19
  • Interference with gastric pH-dependent drug absorption

Contraindications

  • Known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • No adequate and well-controlled studies in pregnant women
  • No teratogenic effects in animal studies
  • Excretion in milk not studied
  • Discontinuation advised if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Instructions for patients taking capsules
  • Use of antacids while taking Pronex

Use in Special Populations

  • Safety and effectiveness not established in paediatric patients
  • No overall differences in safety and efficacy observed in the elderly
  • No dosage adjustment recommended for mild to moderate hepatic insufficiency
  • Pharmacokinetics not expected to be altered in renal impairment

Overdose Effects

  • Adverse effects observed in rats at high doses
  • No specific antidote known
  • Symptomatic and supportive treatment advised

Storage Conditions

  • Store at a temperature not exceeding 30°C in a dry place
  • Protect from light and moisture
  • Keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S

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