Sergel 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 7.00 (10 x 10: ৳ 700.00)
Strip Price: ৳ 70.00

Medicine Details

Category Details
Generic Esomeprazole
Company Healthcare pharmaceuticals ltd
Also available as
Sergel 40 mg capsule Sergel 40 mg injection Sergel 20 mg tablet Sergel 40 mg tablet Sergel 20 mg powder

Title

Sergel 20 mg Capsule

Categories

  • Medicine
  • Pharmaceuticals
  • Gastroenterology

Description

Sergel is a proton pump inhibitor used to relieve chronic heartburn symptoms, heal erosive esophagitis, eradicate Helicobacter pylori infection, treat Zollinger-Ellison Syndrome, acid-related Dyspepsia, and duodenal & gastric ulcers.

Indication

  • Chronic heartburn relief
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment for Zollinger-Ellison Syndrome
  • Treatment for Acid-related Dyspepsia
  • Treatment for Duodenal & Gastric ulcer

Pharmacology

  • Mode of action: Suppresses gastric acid secretion by specific inhibition of the H+/K+-ATPase
  • Absorption: Enteric-coated pellet formulation with peak plasma levels occurring at approximately 1.5 hours
  • Distribution: 97% bound to plasma proteins; apparent volume of distribution at steady state in healthy volunteers is approximately 16 L
  • Metabolism: Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system
  • Excretion: Plasma elimination half-life of approximately 1-1.5 hours; less than 1% of parent drug excreted in the urine

Dosage

  • Oral:
    • Healing of erosive esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
    • Maintenance of healing of erosive esophagitis: 20 mg Once Daily
    • Symptomatic gerd: 20 mg Once Daily for 4 Weeks
    • Helicobacter pylori eradication: 40 mg Once Daily for 10 days
    • Zollinger ellison syndrome: 20-80 mg once daily
    • Acid related dyspepsia: 20-40 mg once daily for 2-4 weeks
    • Duodenal ulcer: 20 mg once daily for 2-4 weeks
    • Gastric ulcer: 20-40 mg once daily for 4-8 weeks
  • Iv injection:
    • Gerd with erosive esophagitis: 20 mg or 40 mg once daily for adult patients; dosage adjustments for pediatric patients
  • Risk reduction of rebleeding of gastric or duodenal ulcers: 80 mg IV Infusion for adults

Administration

  • Tablet or capsule: Swallowed whole and taken one hour before a meal
  • Oral suspension: Mixed with water, stirred well, and should be taken immediately; for administration through a tube, specific instructions apply
  • Iv injection: Administered intravenously over a period of at least 3 minutes

Interaction

  • Metabolism: Extensively metabolized in the liver by CYP2C19 and CYP3A4
  • Interference with absorption: May interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability
  • Co-administration impacts: Potential increases in the plasma levels of certain drugs when co-administered

Contraindications

Contraindicated in patients with known hypersensitivity to any of the formulation

Side effects

  • Headache
  • Diarrhea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy and lactation

  • Pregnancy: No adequate and well-controlled studies in pregnant women; animal studies have revealed no teratogenic effects
  • Lactation: Excretion of esomeprazole in milk has not been studied; breastfeeding should be discontinued if considered essential

Precautions and warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Specific administration instructions for patients with difficulty swallowing capsules

Special populations

  • Paediatric use: Safety and effectiveness not established
  • Geriatric use: No overall differences in safety and efficacy observed between the elderly and younger individuals
  • Hepatic insufficiency: Dose adjustment not recommended for mild to moderate hepatic insufficiency; dosage limitation for severe hepatic insufficiency
  • Renal insufficiency: Pharmacokinetics not expected to be altered in patients with renal impairment

Overdose effects

Major signs of acute toxicity include reduced motor activity, changes in respiratory frequency, tremor, ataxia, and intermittent clonic convulsions

Storage conditions

Store at a temperature not exceeding 30°C in a dry place, protect from light and moisture, keep out of reach of children

Chemical structure

  • Molecular formula: C17H19N3O3S
  • Chemical structure image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Commonly asked questions

  • Overview:
    • Proton pump inhibitor for reducing stomach acid
    • Used to treat various gastrointestinal conditions
  • Uses:
    • Relief of heartburn and GERD symptoms
    • Healing of erosive esophagitis
    • Prevention of erosive esophagitis recurrence
  • Side effects:
    • Headaches
    • Diarrhea
    • Nausea
    • Gas
    • Stomach pain
    • Constipation
    • Dry mouth
  • Pregnancy and breastfeeding: Consult doctor about the risks and benefits
  • Onset of action: Usually starts working within a few hours of taking it
  • Quick tips:
    • Well-tolerated medicine providing long-term relief
    • Avoid late-night eating or bedtime eating
    • Inform doctor about specific symptoms or concerns

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