Sergel 40 mg/vial (IV Injection)

40 mg vial: ৳ 100.00

Medicine Details

Category	Details
Generic	Esomeprazole
Company	Healthcare pharmaceuticals ltd
Also available as	Sergel 20 mg capsule Sergel 40 mg capsule Sergel 20 mg tablet Sergel 40 mg tablet Sergel 20 mg powder

Product Title

Sergel 40 mg/vial Injection

Categories

Medicine
Pharmaceutical

Description

Proton pump inhibitor for relief from chronic heartburn and other symptoms associated with GERD, healing of erosive esophagitis, maintenance of healing of erosive esophagitis, eradication of Helicobacter pylori infection, Zollinger-Ellison Syndrome, acid-related Dyspepsia, Duodenal & Gastric ulcer

Dosage Form

Tablet
Capsule
Oral Suspension
IV Injection
IV Infusion

Dosage Strengths

20 mg
40 mg
10 mg (pediatric patients)
80 mg (adult patients)

Dosage Instructions

Taken one hour before meals
Swallowed whole
Mixed with applesauce for easier swallowing
Injected intravenously over specific time frames

Effectiveness Duration

4-8 weeks for erosive esophagitis healing
Up to 6 months for maintenance of healing
10-day regimen for Helicobacter pylori eradication

Side Effects

Headache
Diarrhea
Nausea
Flatulence
Abdominal pain
Constipation
Dry mouth

Pregnancy & Lactation

No adequate and well-controlled studies in pregnant women
Breastfeeding should be discontinued if essential

Contraindications

Known hypersensitivity to any of the formulation

Storage Conditions

Temperature not exceeding 30°C
Dry place
Protected from light and moisture
Keep out of reach of children

Chemical Structure

Molecular Formula: C17H19N3O3S

Pharmacology

Proton pump inhibitor that suppresses gastric acid secretion
Enteric-coated pellet formulation of esomeprazole magnesium
Extensively metabolized in the liver
97% bound to plasma proteins
Plasma elimination half-life of approximately 1-1.5 hours

Interaction

Extensively metabolized in the liver by CYP2C19 and CYP3A4
Not likely to inhibit certain CYP enzymes
May interfere with the absorption of specific drugs

Interaction with Other Drugs

No clinically significant interactions with phenytoin, warfarin, quinidine, clarithromycin, or amoxicillin
May potentially interfere with CYP2C19, the major metabolizing enzyme

Caution for Patients

Delayed gastric emptying with other drugs
Can be taken with antacids
Appropriate timing with food intake

Usability in Special Populations

Safety and effectiveness not established in pediatric patients
No observed differences in safety and efficacy between elderly and younger individuals
No dosage adjustment recommended for patients with mild to moderate hepatic insufficiency

Overdose Effects

Major signs of acute toxicity include reduced motor activity, respiratory changes, tremor, and convulsions
No specific antidote known
Treatment should be symptomatic and supportive

Pharmacokinetics

Peak plasma levels occur at approximately 1.5 hours after oral administration
Systemic bioavailability is approximately 90% with once daily dosing
Approximately 80% excreted as inactive metabolites in the urine

Risks and Benefits

Symptomatic response does not preclude the presence of gastric malignancy
Talk to your doctor about risks and benefits if pregnant or breastfeeding

Common Questions

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Usage Precautions

Swallowed whole and taken one hour before meals
Avoid late-night eating or bedtime consumption
Consult doctor for any persistent adverse effects

Pediatric and Geriatric Use

No established safety and efficacy for pediatric patients
No observed differences in safety and efficacy between elderly and younger individuals
No dosage adjustment recommended for mild to moderate hepatic insufficiency

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