Xelpro 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 8.00 (3 x 10: ৳ 240.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Esomeprazole
Company Pharmasia limited
Also available as
Xelpro 20 mg tablet Xelpro 20 mg capsule Xelpro 40 mg capsule Xelpro 40 mg injection

Indications

  • Relief from chronic heartburn symptoms
  • Healing of erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Eradication of Helicobacter pylori infection
  • Treatment of Zollinger-Ellison Syndrome
  • Management of acid-related Dyspepsia
  • Treatment of Duodenal & Gastric ulcers

Pharmacology

  • Mode of Action: Proton pump inhibitor
  • Absorption: Enteric-coated pellet formulation
  • Distribution: 97% bound to plasma proteins
  • Metabolism: Extensively metabolized in the liver
  • Excretion: Less than 1% excreted in the urine

Dosage

  • Oral Dosage Form:
    • Healing of Erosive Esophagitis: 20 mg or 40 mg Once Daily for 4-8 Weeks
    • Symptomatic GERD: 20 mg Once Daily for 4 Weeks
    • Zollinger-Ellison Syndrome: 20-80 mg once daily
    • Acid-related Dyspepsia: 20-40 mg once daily for 2-4 weeks
  • IV Injection or IV Infusion: Dosing varies based on patient age, weight, and specific condition

Administration

  • Tablet or capsule: Swallowed whole one hour before a meal
  • Oral Suspension:
    • Stirred with water and consumed within 30 minutes
    • Administered through a nasogastric or gastric tube
  • IV Injection: Intravenously over a period of at least 3 minutes

Interaction

  • Metabolism: Primarily by CYP2C19 and CYP3A4
  • Drug Interactions:
    • Not likely to inhibit CYPs 1A2, 2A6, 2C9, 2D6, 2E1, and 3A4
    • May interfere with the absorption of certain drugs

Contraindications

Hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

No adequate and well-controlled studies; breastfeeding should be discontinued if essential

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric malignancy
  • Detailed instructions for patients on administration

Use in Special Populations

  • Paediatric Use: Safety and effectiveness not established
  • Geriatric Use: Similar safety and efficacy to younger individuals
  • Hepatic Insufficiency: Dose adjustment for severe hepatic insufficiency
  • Renal Insufficiency: Pharmacokinetics not expected to be altered

Overdose Effects

Acute toxicity in animal studies; symptomatic and supportive treatment recommended

Storage Conditions

Store at a temperature not exceeding 30°C, protect from light and moisture, keep out of reach of children

Chemical Structure

  • Molecular Formula: C17H19N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-433-esomeprazole-chemical-structure-Tj2Jfp1VmPkRjNXznKqC.svg

Common Questions

  • What is Xelpro 40 mg Tablet?: Proton pump inhibitor used to treat various conditions related to stomach acid
  • What is Xelpro 40 mg Tablet used for?: Multiple uses including GERD, ulcers, and esophagitis
  • What are the side effects of Xelpro 40 mg Tablet?: Common side effects such as headaches, diarrhea, nausea, etc.
  • Can I take Xelpro 40 mg Tablet if I am pregnant or breastfeeding?: No significant side effects observed in studies

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