Delpino 7.5 mg (Tablet)

Indications

• Symptomatic treatment of chronic stable angina pectoris in coronary artery disease patients with normal sinus rhythm
• In patients unable to tolerate or with a contra-indication to the use of beta-blockers
• In combination with beta-blockers in patients inadequately controlled with an optimal beta-blocker dose and whose heart rate is > 60 bpm

Pharmacology

• Pure heart rate lowering agent
• Selective and specific inhibition of the cardiac pacemaker I f current
• Decreases the cardiac workload and oxygen consumption
• Prolongs diastole allowing increased perfusion of coronary arteries
• No effect on intra-atrial, atrioventricular or intraventricular conduction times, myocardial contractility or ventricular repolarization

Dosage & Administration

• Usual recommended starting dose of 5 mg twice daily
• Increased after 3-4 weeks of treatment to 7.5 mg twice daily
• Usual dose is 1 tablet in the morning and 1 tablet in the evening during meals
• Lower starting dose for elderly patients
• No dose adjustment required in patients with renal insufficiency and creatinine clearance above 15ml/min
• Caution in patients with moderate hepatic impairment
• Not recommended for use in children and adolescents

Interaction

• QT wave prolonging medicinal products is not recommended
• Concomitant use of cardiovascular and non-cardiovascular QT wave prolonging medicinal products with Delpino should be avoided

Contraindications

• History of hypersensitivity to Ivabradine or any of the excipients
• Resting heart rate below 60 bpm before treatment
• Cardiogenic shock, acute myocardial infarction
• Severe hypotension (<90/50 mmHg)
• Severe hepatic insufficiency
• Sick sinus syndrome, sino-atrial block, heart failure
• Pacemaker dependent, unstable angina
• 3rd degree AV block
• Combination with strong cytochrome P-450 3A4 inhibitors

Side Effects

• Visual symptoms, blurred vision
• Bradycardia, 1st degree AV block, ventricular extrasystoles
• Headaches, dizziness

Pregnancy & Lactation

• Contra-indicated during pregnancy
• Excreted in milk, contra-indicated during breast-feeding

Precautions & Warnings

• Mild to moderate hypotension
• Atrial fibrillation
• Patients with congenital QT syndrome or treated with QT wave prolonging medicinal products
• Moderate hepatic insufficiency, severe renal insufficiency

Therapeutic Class

• Other Anti-anginal & Anti-ischaemic drugs

Storage Conditions

• Keep below 30°C temperature
• Away from light & moisture
• Keep out of the reach of children

Related Brands

• Delpino 5 mg (Tablet) - healthcare-pharmaceuticals-ltd
• Ivacard 5 mg (Tablet) - aristopharma-ltd
• Ivacard 7.5 mg (Tablet) - aristopharma-ltd