Lansec 15 mg (Capsule (Enteric Coated))

Unit Price: ৳ 3.55 (6 x 10: ৳ 213.00)

Strip Price: ৳ 35.50

Medicine Details

Category	Details
Generic	Lansoprazole
Company	Drug international ltd
Also available as	Lansec 30 mg capsule

Indications

Short term treatment of active duodenal ulcer
Maintenance of healed duodenal ulcers
Short term treatment of active benign gastric ulcers
Short term treatment of active erosive esophagitis
Maintenance of healing of erosive esophagitis
Pathological hypersecretory conditions including Zollinger- Ellison Syndrome
H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Pharmacology

Lansoprazole is a substituted benzimidazole, and is also known as PPI due to its property to block the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.

Dosage & Administration

Benign gastric ulcer: 30 mg daily in the morning for 8 weeks
Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg
NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed
Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses
Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily
Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks

Interaction

Lansec appears to be a selective inhibitor of the cytochrome P-450 monooxygenase system; there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Lansec on the oral combined contraceptive pill. Further assessment is currently underway. Physiological changes similar to those found with Omeprazole are likely to take place because of the reduction in gastric acid, which is likely to influence the bacterial colonization of the stomach and duodenum and also vitamin B12 absorption.

Contraindications

Lansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation.

Side Effects

The possible induction of carcinoid tumors by profound acid suppression, and a rise in serum gastrin may occur
Dose dependent diarrhea occurs with an incidence of about 4% at 30 mg per day, rising to 8% at 60 mg per day
Headache occurs in 2-3% of treated patients

Pregnancy & Lactation

Lansoprazole should be avoided in pregnancy unless there are compelling reasons.

Precautions & Warnings

Gastric malignancy should be ruled out
Hepatic impairment
Pregnancy and lactation

Use in Special Populations

Neonates: There is no relevant human data. The drug is not recommended for use with neonates
Children: The youngest person to have received Lansec in clinical trials was 13 years old
The Elderly: No problems have been encountered in clinical use and there has been no increase in adverse drug reaction in the elderly