Lansec 30 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.05 (5 x 10: ৳ 302.50)
Strip Price: ৳ 60.50

Medicine Details

Category Details
Generic Lansoprazole
Company Drug international ltd
Also available as
Lansec 15 mg capsule

Indications

  • Short term treatment of active duodenal ulcer
  • Maintenance of healed duodenal ulcers
  • Short term treatment of active benign gastric ulcers
  • Short term treatment of active erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Pathological hypersecretory conditions including Zollinger-Ellison Syndrome
  • H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Pharmacology

  • Substituted benzimidazole
  • PPI (Proton Pump Inhibitor)
  • Blocks final step of acid secretion
  • Inhibits H+/K+ ATPase enzyme system
  • Inhibits both basal and stimulated acid

Dosage & Administration

  • 30 mg daily in the morning for benign gastric ulcer for 8 weeks
  • 30 mg daily in the morning for duodenal ulcer for 4 weeks; maintenance 15 mg
  • 15-30 mg daily for NSAID-associated duodenal or gastric ulcer
  • Initially 60 mg once daily for Zollinger-Ellison syndrome; daily doses of 120 mg or more given in two divided doses
  • 30 mg daily in the morning for gastroesophageal reflux disease for 4 weeks; maintenance 15-30 mg daily
  • 15-30 mg daily in the morning for acid-related dyspepsia for 2-4 weeks

Interaction

  • Selective inhibitor of the cytochrome P-450 monooxygenase system
  • Effect on hepatic clearance
  • No clinically relevant interactions reported
  • Uncertain effect on the oral combined contraceptive pill
  • Likely reduction in gastric acid influencing bacterial colonization and vitamin B12 absorption

Contraindications

  • Known hypersensitivity to any component of the formulation

Side Effects

  • Possible induction of carcinoid tumors by profound acid suppression
  • Rise in serum gastrin levels
  • Long term treatment may accelerate the development of atrophic gastritis
  • Dose dependent diarrhea with an incidence of about 4% at 30 mg per day
  • Headache occurs in 2-3% of treated patients

Pregnancy & Lactation

  • Should be avoided in pregnancy unless there are compelling reasons

Precautions & Warnings

  • Gastric malignancy should be ruled out
  • Hepatic impairment
  • Pregnancy and lactation

Use in Special Populations

  • Neonates: Not recommended
  • Children: Minimum age in clinical trials was 13 years old
  • Elderly: No increase in adverse drug reaction reported

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Store at 25°C

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