Kentop 100 mg (Tablet (Enteric Coated))
Unit Price: ৳ 4.55 (50's pack: ৳ 227.50)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketoprofen oral injection |
| Company | Premier pharmaceuticals ltd |
Indications
- Rheumatoid arthritis
- Degenerative joint diseases
- Musculoskeletal and joint disorders
- Tendinitis
- Sprain
- Dental pain
- Headache
- Primary dysmenorrhea
Pharmacology
- Non-steroidal anti-inflammatory drug (NSAID)
- Analgesic
- Antipyretic
- Inhibition of prostaglandin synthesis
- Stabilization of lysosomal membranes
- Inhibition of leukotriene synthesis
- Antibradykinin activity
- Peripheral and central analgesia
- Hypothalamic prostaglandin synthesis suppression
- Rapid and complete absorption from GI tract
- High plasma protein binding
- Metabolism in the liver
- Excretion in urine and faeces
- Peak concentration after IM injection
- Short elimination half-life
Dosage
- Anti-inflammatory starting dose
- Maintenance dosage
- Maximum daily dose
- Pain management dose
- Frequency of dosing
- Administration with fluids
- Administration with food
Interaction
- NSAID and salicylates combination risk
- Anticoagulant interaction
- Lithium level elevation risk
- Methotrexate toxicity risk
- Medications promoting hyperkalemia
- Corticosteroid interaction
- Diuretic interaction
- ACE inhibitor and diuretic co-administration
- Nicorandil interaction
- Cardiac glycoside caution
- Cyclosporin interaction
- Tacrolimus interaction
- Pentoxifylline interaction
- Tenofovir coadministration risk
- Antihypertensive agents impact
- Thrombolytic interaction
- Probenecid impact
- Selective serotonin reuptake inhibitors (SSRIs) interaction
Contraindications
- Hypersensitivity reactions
- Severe heart failure
- Peptic ulcer/hemorrhage
- Gastrointestinal bleeding or perforation history
- Severe hepatic insufficiency
- Severe renal insufficiency
- Third trimester of pregnancy
- Rectitis or history of proctorrhagia
Side Effects
- Blood and lymphatic system disorders
- Immune system disorders
- Nervous system disorders
- Eye disorders
- Ear and labyrinth disorders
- Cardiac disorders
- Vascular disorders
- Respiratory, thoracic and mediastinal disorders
- Gastrointestinal disorders
- Hepatobiliary disorders
- Skin and subcutaneous disorders
- Renal and urinary disorders
- General disorders and administration site conditions
- Metabolism and nutritional disorders
- Investigations
Pregnancy & Lactation
- Use avoidance in first and second trimester
- Contraindication in third trimester
- Not recommended during breastfeeding
Precautions & Warnings
- Caution in gastrointestinal disease history
- Renal function monitoring
- Fluid retention and oedema risk
- Atrial fibrillation risk
- Hyperkalemia risk
- Masking of infection signs
- Liver function test evaluation
- Visual disturbances caution
- Female fertility impairment
- Elderly dosage adjustment
- Hepatic impairment monitoring
- Renal impairment dosage adjustment
Use in Special Populations
- Elderly dosage reduction
- Hepatic impairment monitoring
- Renal impairment dosage adjustment
Overdose Effects
- Symptoms
- Benign overdose instances
- Gastric lavage recommendation
- Supportive treatment
- Dehydration compensation
- Urinary excretion monitoring
- Acidosis correction
- Hemodialysis in renal failure
Therapeutic Class
- Osteoarthritis drugs
- Rheumatoid arthritis drugs
- NSAIDs
Storage Conditions
- Light protection
- Temperature control
- Expiry date adherence
- Childproof storage
- Prescription requirement