Profenid-CR 200 mg (Capsule (Controlled Release))

Unit Price: ৳ 20.06 (5 x 10: ৳ 1,003.00)
Strip Price: ৳ 200.60

Medicine Details

Category Details
Generic Ketoprofen oral injection
Company Synovia pharma plc
Also available as
Profenid e 50 mg tablet Profenid e 100 mg tablet Profenid 100 mg injection Profenid cr 100 mg capsule

Indications

  • Rheumatoid arthritis
  • Degenerative joint diseases
  • Musculoskeletal disorders
  • Dental pain
  • Headache
  • Dysmenorrhea

Pharmacology

  • Anti-inflammatory
  • Analgesic
  • Antipyretic
  • Prostaglandin synthesis inhibition
  • Lysosomal membrane stabilization
  • Leukotriene synthesis inhibition
  • Antibradykinin activity
  • Central nervous system suppression

Dosage

  • 150-300mg/day for anti-inflammatory
  • 25-50mg every 6-8 hours for pain
  • Maximum daily dose of 300mg

Administration

  • Oral intake with fluids
  • Preferably taken with food

Interactions

  • NSAIDs interactions
  • Anticoagulant interactions
  • Lithium interaction
  • Methotrexate interaction
  • Potassium-promoting drug interactions
  • Corticosteroid interaction
  • Diuretic interaction
  • ACE inhibitor and Angiotensin II antagonist interaction
  • Cardiac glycoside interaction
  • Cyclosporin interaction
  • Tacrolimus interaction
  • Pentoxifylline interaction
  • Tenofovir interaction
  • Antihypertensive agents interaction
  • Thrombolytic interaction
  • Probenecid interaction
  • SSRIs interaction

Contraindications

  • Hypersensitivity reactions
  • Severe heart failure
  • Peptic ulcer/hemorrhage
  • Gastrointestinal bleeding or perforation
  • Severe hepatic insufficiency
  • Severe renal insufficiency
  • Third trimester of pregnancy
  • Rectitis or history of proctorrhagia

Side Effects

  • Haemorrhagic anaemia
  • Agranulocytosis
  • Thrombocytopenia
  • Depression
  • Somnolence
  • Aseptic meningitis
  • Tinnitus
  • Exacerbation of heart failure
  • Asthma
  • Dyspepsia
  • Nausea
  • Hepatitis
  • Rash
  • Oedema
  • Hyponatremia
  • Weight increased

Pregnancy & Lactation

  • Avoid in first and second trimester
  • Contraindicated in third trimester
  • Not recommended in nursing mothers

Precautions & Warnings

  • Careful with history of gastrointestinal disease
  • Monitor renal function in heart failure, cirrhosis, nephrosis
  • Caution in hypertension and congestive heart failure
  • Increased risk of atrial fibrillation
  • Hyperkalemia monitoring in diabetes, renal failure
  • Masking of signs of infection progression
  • Monitoring of liver function tests
  • Discontinue in case of visual disturbances
  • Impairment of female fertility
  • Consider withdrawal in women attempting to conceive

Use in Special Populations

  • Elderly - reduce initial dosage
  • Hepatic impairment - monitor and minimize dosage
  • Renal impairment - reduce initial dosage

Overdose Effects

  • Benign symptoms at overdose up to 2.5g ketoprofen
  • Symptomatic and supportive treatment
  • Gastric lavage in suspected massive overdoses
  • Hemodialysis in renal failure

Therapeutic Class

  • Osteoarthritis drugs
  • Rheumatoid arthritis drugs
  • NSAIDs

Storage Conditions

  • Protect from light
  • Store below 30°C
  • Do not use after expiry date
  • Keep out of reach of children
  • Dispense only on prescription

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