Roket 60 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 95.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Globe pharmaceuticals ltd
Also available as
Roket 30 mg injection Roket 10 mg tablet

Indications

  • Short-term management of post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decreasing eye inflammation or redness caused by seasonal allergies

Description

  • Pyrrolo-pyrrole group nonsteroidal anti-inflammatory drug
  • Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits prostaglandin synthesis
  • S-form associated biological activity
  • Linear pharmacokinetic property
  • Highly protein bound
  • Metabolized in the liver
  • Excretion in urine

Pharmacology

  • Potent analgesic
  • Inhibition of cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose of 10 mg every 4-6 hours for short-term use
  • Injection: Single or multiple doses for moderately severe, acute pain
  • Different dosing for patients of different age groups and renal function
  • Maximum daily doses for different patient groups
  • Eye Drops: Recommended administration of 1 drop in each eye 4 times daily

Interaction

  • Enhanced side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with beta blockers
  • Increased risk of renal impairment with ACE inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Use not recommended for children under 16 years of age
  • Not to be used as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category C
  • Avoid use in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years of age
  • Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use in the case of corneal epithelial breakdown
  • Avoid use while wearing contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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