Surpim 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 54.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Asiatic laboratories ltd
Also available as
Surpim 10 mg tablet Surpim 05 eye drop

Indications

  • Short-term management of post-operative pain
  • Relief from inflammation and light sensitivity after ocular surgery
  • Reduction of eye inflammation or redness due to seasonal allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits prostaglandins synthesis
  • Associated with the S-form
  • Highly protein bound and metabolized in the liver

Pharmacology

  • Potent analgesic
  • Inhibits cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use
  • Injection: Used for moderately severe acute pain management, with specific dosages for different age groups and conditions
  • Eye Drops: Adult dosage is 1 drop in each eye 4 times daily

Interaction

  • NSAIDs or aspirin: Increases side effects
  • Anti-coagulants: Enhances anti-coagulant effect
  • Beta Blocker: Reduces anti-hypertensive effect
  • ACE Inhibitors: Increases risk of renal impairment
  • Methotrexate: Enhances toxicity of methotrexate

Contraindications

  • Hypersensitivity to drug or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melana
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoid in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Exercise caution in patients over 65 years
  • Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • For Eye Drops: Discontinue if corneal epithelial breakdown is observed, and avoid use with contact lenses

Therapeutic Class

  • Rheumatoid Arthritis Drugs
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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