Surpim 30 mg/ml (IM/IV Injection)
1 ml ampoule: ৳ 54.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Asiatic laboratories ltd |
| Also available as |
Indications
- Short-term management of post-operative pain
- Relief from inflammation and light sensitivity after ocular surgery
- Reduction of eye inflammation or redness due to seasonal allergies
Description
- Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAID)
- Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits prostaglandins synthesis
- Associated with the S-form
- Highly protein bound and metabolized in the liver
Pharmacology
- Potent analgesic
- Inhibits cyclooxygenase enzyme system
- Minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use
- Injection: Used for moderately severe acute pain management, with specific dosages for different age groups and conditions
- Eye Drops: Adult dosage is 1 drop in each eye 4 times daily
Interaction
- NSAIDs or aspirin: Increases side effects
- Anti-coagulants: Enhances anti-coagulant effect
- Beta Blocker: Reduces anti-hypertensive effect
- ACE Inhibitors: Increases risk of renal impairment
- Methotrexate: Enhances toxicity of methotrexate
Contraindications
- Hypersensitivity to drug or other NSAIDs
- Children under 16 years of age
- Prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melana
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category: C
- Avoid in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Exercise caution in patients over 65 years
- Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
- For Eye Drops: Discontinue if corneal epithelial breakdown is observed, and avoid use with contact lenses
Therapeutic Class
- Rheumatoid Arthritis Drugs
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children