KTL 10 mg (Tablet)

Unit Price: ৳ 8.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Aztec pharmaceuticals ltd

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease in eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits prostaglandin synthesis
  • Biological activity associated with the S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Largely metabolized in the liver
  • Metabolites and some unchanged drug excreted in urine

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet recommended dose: 10 mg every 4-6 hours
  • Tablet not recommended for chronic use
  • Injection may be used for moderately severe, acute pain management
  • Recommended IV bolus administration over at least 15 seconds
  • Recommended IM administration slowly and deeply into the muscle
  • Onset of analgesic effect within 30 minutes (IV or IM)
  • Maximum analgesic effect in 1 to 2 hours (IV or IM)
  • Duration of analgesic effect usually 4 to 6 hours
  • Different dosing for various age groups and conditions
  • Eye Drops: 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin: Increase side effects of KTL
  • Anti-coagulants: Enhance anti-coagulant effect
  • Beta Blocker: Reduce anti-hypertensive effect
  • ACE Inhibitors: Increase risk of renal impairment
  • Methotrexate: Enhance toxicity of methotrexate

Contraindications

  • Hypersensitivity to KTL or other NSAIDs
  • Not to be used in children under 16 years of age
  • Contraindicated as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoid in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over the age of 65 years
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use of topical NSAIDs and monitor for corneal health in patients with corneal epithelial breakdown
  • Avoid administration while wearing contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Store in a dry place away from light and heat
  • Keep out of the reach of children

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