Ket 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 55.00 (1 x 5: ৳ 275.00)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Delta pharma ltd
Also available as
Ket 10 mg tablet

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemically known as 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins as a peripherally acting analgesic
  • Biological activity associated with the S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Metabolized in the liver
  • Excretion in the urine

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Acts by inhibiting the cyclooxygenase enzyme system
  • Minimally anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Recommended tablet dose of 10 mg every 4-6 hours for short-term use
  • Injection may be used for acute pain management, with specific dosing guidelines based on age, weight, and renal function

Interaction

  • Increased side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with beta blockers
  • Increased risk of renal impairment with ACE Inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic use before surgery

Side Effects

  • Nausea, vomiting, and gastrointestinal bleeding
  • Melena, peptic ulcer, and pancreatitis
  • Anxiety, drowsiness, and headache
  • Excessive thirst and fatigue
  • Bradycardia, hypertension, and palpitation
  • Chest pain, infertility in females, and pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category C - avoid in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years, active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use in patients with corneal epithelial breakdown
  • Avoid administration while wearing contact lenses

Therapeutic Class

  • Used for Rheumatoid Arthritis and as Non-Opioid Analgesic

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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