K-Lac 10 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Ethical drugs limited
Also available as
K lac 60 mg injection K lac 30 mg injection

Indications

  • Management of moderate to severe post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5-benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Peripherally acting analgesic
  • Highly protein bound
  • Metabolized in the liver
  • Excretion in the urine

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits the cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Injection: Used for management of moderately severe, acute pain in postoperative setting
  • Analgesic effect begins within 30 minutes for IV or IM administration
  • Eye Drops: Adult dosage is 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin: Increases side effects of K-Lac
  • Anti-coagulants: Enhances anti-coagulant effect
  • Beta Blocker: Reduces anti-hypertensive effect
  • ACE Inhibitors: Increases risk of renal impairment
  • Methotrexate: Enhances toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Contraindicated in children under 16 years of age
  • Contraindicated as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoid in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use of topical NSAIDs with evidence of corneal epithelial breakdown
  • Monitor corneal health in case of corneal epithelial breakdown
  • Avoid administration while wearing contact lenses for ophthalmic solution

Therapeutic Class

  • Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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