Lansodin 30 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.02 (7 x 4: ৳ 168.56)

Strip Price: ৳ 24.08

Medicine Details

Category	Details
Generic	Lansoprazole
Company	Acme laboratories ltd
Also available as	Lansodin 15 mg capsule

Indications

Short term treatment of active duodenal ulcer
Maintenance of healed duodenal ulcers
Short term treatment of active benign gastric ulcers
Short term treatment of active erosive esophagitis
Maintenance of healing of erosive esophagitis
Pathological hypersecretory conditions including Zollinger-Ellison Syndrome
H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Pharmacology

Substituted benzimidazole, PPI, blocks the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cell; inhibits both basal and stimulated acid

Dosage & Administration

Benign gastric ulcer: 30 mg daily in the morning for 8 weeks
Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg
NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks, followed by a further 4 weeks if not fully healed
Zollinger-Ellison syndrome (and other hypersecretory conditions): Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses
Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance 15-30 mg daily
Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks

Interaction

Selective inhibitor of the cytochrome P-450 monooxygenase system; potential effect on hepatic clearance, uncertain impact on oral combined contraceptive pill; physiological changes similar to those caused by omeprazole

Contraindications

Known hypersensitivity to any component of the formulation

Side Effects

Possible induction of carcinoid tumors by profound acid suppression; rise in serum gastrin levels
Long term treatment with a proton pump inhibitor in patients with Helicobacter pylori infection may accelerate the development of atrophic gastritis
Dose dependent diarrhea, headache

Pregnancy & Lactation

Avoided in pregnancy unless there are compelling reasons

Precautions & Warnings

Gastric malignancy should be ruled out; hepatic impairment; pregnancy and lactation

Use in Special Populations

Neonates: Not recommended for use
Children: The youngest person to have received Lansodin in clinical trials was 13 years old
The Elderly: No problems encountered in clinical use; no increase in adverse drug reactions