Ketoropack 10 mg (Tablet)
Unit Price: ৳ 10.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Marksman pharmaceuticals ltd |
Indications
- Short-term management of post-operative pain
- Relieves pain after ocular surgery
- Relieves inflammation after ocular surgery
- Decreases eye inflammation caused by allergies
- Reduces light sensitivity after ocular surgery
Description
- Belongs to pyrrolo-pyrrole group of NSAIDs
- Chemically known as 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid
- Inhibits synthesis of prostaglandins
- Considered as a peripherally acting analgesic
- Biological activity associated with the S-form
- Linear pharmacokinetic property
- Highly protein bound
- Metabolized in the liver
- Metabolites excreted in the urine
Pharmacology
- Potent analgesic NSAID
- Inhibits cyclooxygenase enzyme system
- Minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet recommended dose of 10 mg every 4-6 hours
- Injection recommended for moderate to severe acute pain management
- IV bolus administration over 15 seconds
- IM administration given slowly and deeply into the muscle
- Analgesic effect begins within 30 minutes
- Maximum effect in 1 to 2 hours after dosing IV or IM
- Duration of analgesic effect is 4 to 6 hours
- Different dosing recommendations for age groups and conditions
- Recommended maximum daily doses for different populations
- Usage instructions for eye drops
Interaction
- Increased side effects with other NSAIDs or aspirin
- Enhanced anti-coagulant effect with anti-coagulants
- Reduced anti-hypertensive effect with beta blockers
- Increased risk of renal impairment with ACE inhibitors
- Enhanced toxicity of methotrexate
Contraindications
- Hypersensitivity to Ketorolac and other NSAIDs
- Not recommended for children under 16 years of age
- Contraindicated as prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melena
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- FDA Pregnancy category C
- Avoided in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Caution in patients over 65 years
- Caution in patients with active or suspected peptic ulcer or gastrointestinal bleeding
- Caution in patients with asthma and liver dysfunction
- Discontinue use immediately if evidence of corneal epithelial breakdown
- Not to be administered while wearing contact lenses
Therapeutic Class
- Drugs for Rheumatoid Arthritis
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of reach of children