Painfree 10 mg (Tablet)

Unit Price: ৳ 10.00 (40's pack: ৳ 400.00)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Quality pharmaceuticals ltd

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease eye inflammation or redness caused by seasonal allergies

Description

  • Drug of pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Peripherally acting analgesic
  • Biological activity associated with the S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Metabolized in the liver
  • Excretion in urine

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits the cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet recommended dose: 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Injection dosage varies based on age, weight, and condition
  • IM or IV administration with specific doses for different age groups
  • Onset of analgesic effect within 30 minutes, maximum effect in 1 to 2 hours, duration of 4 to 6 hours
  • Oral administration for eye drops

Interaction

  • Increased side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with beta blockers
  • Increased risk of renal impairment with ACE inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to the drug or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in female
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoid in pregnancy and lactation unless benefits outweigh the risks

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
  • Caution in patients with evidence of corneal epithelial breakdown when using eye drops
  • Monitoring of corneal health for patients using topical NSAIDs
  • Avoid administration while wearing contact lenses for ophthalmic solution

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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