Ketoprix 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 55.17 (1 x 5: ৳ 275.85)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Sharif pharmaceuticals ltd
Also available as
Ketoprix 10 mg tablet Ketoprix 60 mg injection

Indications

  • Management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease eye inflammation or redness caused by seasonal allergies

Description

  • Pyrrolo-pyrrole group
  • Nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Peripherally acting analgesic
  • Biological activity associated with S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Metabolized in liver
  • Excretion in urine

Pharmacology

  • Potent analgesic
  • Inhibits cyclooxygenase enzyme system
  • Inhibits prostaglandin synthesis
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Injection: Single or multiple doses for moderately severe, acute pain
  • Onset of analgesic effect within 30 minutes (IV or IM)

Interaction

  • Other NSAIDs or aspirin: Increases side effects of Ketoprix
  • Anti-coagulants: Enhances anti-coagulant effect
  • Beta Blocker: Reduces anti-hypertensive effect
  • ACE Inhibitors: Increases risk of renal impairment
  • Methotrexate: Enhances toxicity

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category C
  • Avoided in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Eye Drops: Discontinue if corneal epithelial breakdown is detected, monitor corneal health, not to be used with contact lenses

Therapeutic Class

  • Rheumatoid Arthritis drugs
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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