Lantid 30 mg (Capsule (Enteric Coated))

Unit Price: ৳ 5.02 (3 x 6: ৳ 90.36)

Strip Price: ৳ 30.12

Medicine Details

Category	Details
Generic	Lansoprazole
Company	Opsonin pharma ltd

Indications

Short-term treatment of active duodenal ulcer
Maintenance of healed duodenal ulcers
Short-term treatment of active benign gastric ulcers
Short-term treatment of active erosive esophagitis
Maintenance of healing of erosive esophagitis
Pathological hypersecretory conditions including Zollinger-Ellison Syndrome
H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Pharmacology

Lansoprazole is a substituted benzimidazole, and is also known as PPI due to its property to block the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cell. Both basal and stimulated acid are inhibited.

Dosage & Administration

30 mg daily in the morning for benign gastric ulcer for 8 weeks
30 mg daily in the morning for duodenal ulcer for 4 weeks; maintenance 15 mg
15-30 mg daily for NSAID-associated duodenal or gastric ulcer
Initially 60 mg once daily for Zollinger-Ellison syndrome; adjusted according to response
30 mg daily in the morning for gastroesophageal reflux disease for 4 weeks
15-30 mg daily in the morning for acid-related dyspepsia for 2-4 weeks

Interaction

Lantid appears to be a selective inhibitor of the cytochrome P-450 monooxygenase system; there may be an effect on hepatic clearance, but there have been no reports to date of clinically relevant interactions. There is some uncertainty over the effect of Lantid on the oral combined contraceptive pill. Physiological changes similar to those found with omeprazole are likely to occur due to the reduction in gastric acid, which may influence the bacterial colonization of the stomach and duodenum and vitamin B12 absorption.

Contraindications

Lansoprazole is contraindicated in patients with known hypersensitivity to any component of the formulation.

Side Effects

Possible induction of carcinoid tumors by profound acid suppression
Rise in serum gastrin levels
Long-term treatment may accelerate the development of atrophic gastritis
Dose dependent diarrhea
Headache

Pregnancy & Lactation

Lansoprazole should be avoided in pregnancy unless there are compelling reasons.

Precautions & Warnings

Gastric malignancy should be ruled out
Hepatic impairment
Pregnancy and lactation

Use in Special Populations

Neonates: Not recommended
Children: The youngest person to have received Lantid in clinical trials was 13 years old
The Elderly: No increase in adverse drug reaction