Protolan 30 mg (Capsule (Enteric Coated))

Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Lansoprazole
Company Beximco pharmaceuticals ltd

Indications

  • Short term treatment of active duodenal ulcer
  • Maintenance of healed duodenal ulcers
  • Short term treatment of active benign gastric ulcers
  • Short term treatment of active erosive esophagitis
  • Maintenance of healing of erosive esophagitis
  • Pathological hypersecretory conditions including Zollinger-Ellison Syndrome
  • H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Pharmacology

  • Substituted benzimidazole
  • PPI - Proton Pump Inhibitor
  • Blocks final step of acid secretion
  • Inhibits H+/K+ ATPase enzyme system in gastric parietal cell
  • Inhibits both basal and stimulated acid

Dosage & Administration

  • Benign gastric ulcer: 30 mg daily in the morning for 8 weeks
  • Duodenal ulcer: 30 mg daily in the morning for 4 weeks; maintenance 15 mg
  • NSAID-associated duodenal or gastric ulcer: 15-30 mg daily for 4 weeks
  • Zollinger-Ellison syndrome: Initially 60 mg once daily adjusted according to response; daily doses of 120 mg or more is given in two divided doses
  • Gastroesophageal reflux disease: 30 mg daily in the morning for 4 weeks; maintenance 15-30 mg daily
  • Acid-related dyspepsia: 15-30 mg daily in the morning for 2-4 weeks

Interaction

  • Selective inhibitor of the cytochrome P-450 monooxygenase system
  • Effect on hepatic clearance
  • No clinically relevant interactions reported
  • Uncertainty over effect on oral combined contraceptive pill
  • Reduction in gastric acid likely to influence bacterial colonization
  • Reduction in gastric acid likely to influence vitamin B12 absorption

Contraindications

  • Known hypersensitivity to any component of the formulation

Side Effects

  • Possible induction of carcinoid tumors by profound acid suppression
  • Rise in serum gastrin levels
  • Long term treatment may accelerate the development of atrophic gastritis
  • Dose dependent diarrhea
  • Headache

Pregnancy & Lactation

  • Lansoprazole should be avoided in pregnancy unless there are compelling reasons

Precautions & Warnings

  • Rule out gastric malignancy
  • Hepatic impairment
  • Pregnancy and lactation

Use in Special Populations

  • Neonates: Not recommended for use with neonates
  • Children: The youngest person to have received Protolan in clinical trials was 13 years old
  • Elderly: No increase in adverse drug reaction

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Store at 25° C

Related Brands