Lamicet 50 mg (Tablet)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Lamotrigine |
| Company | Square pharmaceuticals plc |
Indications
- Epilepsy- adjunctive therapy in patients aged 2 years and older
- Partial-onset seizures
- Primary generalized tonic-clonic seizures
- Generalized seizures of Lennox-Gastaut syndrome
- Epilepsy- monotherapy in patients aged 16 years and older
- Bipolar disorder- patients aged 18 years and older
Description
Phenyltriazine antiepileptic used to treat epilepsy and bipolar disorder. Controls seizures by inhibiting voltage-sensitive sodium channels and stabilizing neuronal membranes.
Mode of Action
Inhibits voltage-sensitive sodium channels, modulates release of presynaptic excitatory neurotransmitters, weakly binds to various receptors, inhibits Cav2.3 (R-type) calcium currents.
Dosage & Administration
- Week-based escalation regimen for epilepsy in patients older than 12 years
- Usual maintenance doses for different patient groups
- Initial weight-based dosing guide for patients aged 2 to 12 years taking Valproate
- Escalation regimen for bipolar disorder in adults
Interaction
- Valproate increases concentrations by more than 2-fold
- Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease concentrations by approximately 40%
- Estrogen-containing oral contraceptives decrease concentrations by approximately 50%
- Protease inhibitors decrease exposure by approximately 32-50%
Side Effects
- Dizziness
- Headache
- Diplopia
- Ataxia
- Nausea
- Blurred vision
- Somnolence
- Pharyngitis
- Rash
- Vomiting
- Diarrhea
- Infection
- Fever
- Abdominal pain
- Tremor
Pregnancy & Lactation
- Pregnancy Category C
- Excreted in human milk
- Potential for serious adverse reactions in nursing infants
- Decision on nursing or drug discontinuation
Precautions & Warnings
- Discontinue at first sign of rash
- Monitor for blood dyscrasias
- Monitor for suicidal behavior and ideation
- Monitor for aseptic meningitis
Use in Special Populations
- Safety and effectiveness not demonstrated in very young pediatric patients for epilepsy
- Safety and effectiveness not established in pediatric patients for bipolar disorder
Overdose Effects
- Ataxia
- Nystagmus
- Seizures
- Decreased level of consciousness
- Coma
- Intraventricular conduction delay
Therapeutic Class
Primary anti-epileptic drugs
Storage Conditions
Keep out of reach of children, Store in a dry place, below 25°C temperature and protected from light.