Lamogin 50 mg (Tablet)

Unit Price: ৳ 18.00 (3 x 10: ৳ 540.00)
Strip Price: ৳ 180.00

Medicine Details

Indications

  • Adjunctive therapy for partial-onset seizures
  • Adjunctive therapy for primary generalized tonic-clonic seizures
  • Adjunctive therapy for generalized seizures of Lennox-Gastaut syndrome
  • Monotherapy for epilepsy in patients aged 16 years and older
  • Treatment of bipolar disorder in patients aged 18 years and older

Description

  • Phenyltriazine antiepileptic
  • Used to treat some types of epilepsy and bipolar disorder
  • Controls epileptic seizures by inhibiting voltage-sensitive sodium channels
  • Stabilizes neuronal membranes
  • Inhibits presynaptic excitatory neurotransmitter release

Pharmacology

  • Inhibits voltage-sensitive sodium channels
  • Modulates the release of presynaptic excitatory neurotransmitters
  • Binds to inactive sodium channels
  • Suppresses the release of glutamate, an excitatory amino acid
  • Binds to serotonin 5-HT3 receptor weakly
  • Displays weak binding properties to Adenosine A1/A2 receptors, α1/α2/β adrenergic receptors, dopamine D1/D2 receptors, GABA A/B receptors, histamine H1 receptors, κ-opioid receptor, mACh receptors
  • Weakly binds to sigma opioid receptors
  • Inhibits Cav2.3 (R-type) calcium currents

Dosage & Administration

  • Escalation regimen for Lamotrigine in epilepsy patients older than 12 years
  • Escalation regimen for Lamotrigine in epilepsy patients aged 2 to 12 years
  • Escalation regimen for Lamotrigine in adults with bipolar disorder
  • Initial weight-based dosing guide for patients aged 2 to 12 years taking Valproate with epilepsy

Interaction

  • Valproate increases Lamogin concentrations more than 2-fold
  • Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease Lamogin concentrations by approximately 40%
  • Estrogen-containing oral contraceptives decrease Lamogin concentrations by approximately 50%
  • Protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir decrease Lamogin exposure by approximately 50% and 32% respectively

Side Effects

  • Dizziness
  • Headache
  • Diplopia
  • Ataxia
  • Nausea
  • Blurred vision
  • Somnolence
  • Pharyngitis
  • Rash
  • Vomiting (in children)
  • Diarrhea (in children)
  • Infection (in children)
  • Fever (in children)
  • Abdominal pain (in children)
  • Tremor (in children)

Pregnancy & Lactation

  • Pregnancy Category C
  • Excreted in human milk
  • Potential for serious adverse reactions in nursing infants
  • Decision should be made whether to discontinue nursing or discontinue the drug

Precautions & Warnings

  • Discontinue at the first sign of rash
  • Monitor for blood dyscrasias
  • Monitor for signs of anemia, unexpected infection, or bleeding
  • Monitor for suicidal thoughts or behaviors
  • Monitor for signs of aseptic meningitis

Use in Special Populations

  • Safety and effectiveness of Lamogin as adjunctive treatment for partial onset seizures not demonstrated in very young pediatric patients aged 1 to 24 months
  • Safety and effectiveness of Lamogin for the maintenance treatment of bipolar disorder not established in pediatric patients aged 10 to 17 years

Overdose Effects

  • Ataxia
  • Nystagmus
  • Seizures (including tonic-clonic seizures)
  • Decreased level of consciousness
  • Coma
  • Intraventricular conduction delay

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Keep out of reach of children
  • Store in a dry place
  • Below 25°C temperature
  • Protected from light

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