Lamogin 25 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Lamotrigine |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Adjunctive therapy for partial-onset seizures
- Adjunctive therapy for primary generalized tonic-clonic seizures
- Adjunctive therapy for generalized seizures of Lennox-Gastaut syndrome
- Monotherapy for epilepsy in patients aged 16 years and older
- Treatment of bipolar disorder in patients aged 18 years and older
Description
- Phenyltriazine antiepileptic medication
- Used to control epileptic seizures
- Inhibits voltage-sensitive sodium channels
- Stabilizes neuronal membranes
- Inhibits presynaptic excitatory neurotransmitter release
Pharmacology
- Inhibits voltage-sensitive sodium channels
- Modulates release of presynaptic excitatory neurotransmitters
- Weak inhibitory effect on serotonin 5-HT3 receptor
- Binds weakly to multiple receptors including adrenergic, dopamine, and GABA receptors
- Inhibits Cav2.3 (R-type) calcium currents
- May have clinical benefit in some neuropathic pain states
Dosage & Administration
- Dosing regimen for patients older than 12 years with epilepsy
- Dosing regimen for patients aged 2 to 12 years with epilepsy
- Dosing regimen for adults with bipolar disorder
Interaction
- Valproate increases Lamogin concentrations more than 2-fold
- Carbamazepine, phenytoin, phenobarbital, primidone, and rifampin decrease Lamogin concentrations by approximately 40%
- Estrogen-containing oral contraceptives decrease Lamogin concentrations by approximately 50%
- Protease inhibitors lopinavir/ritonavir and atazanavir/ritonavir decrease Lamogin exposure by approximately 50% and 32% respectively
Side Effects
- Dizziness
- Headache
- Diplopia
- Ataxia
- Nausea
- Blurred vision
- Somnolence
- Pharyngitis
- Rash
- Vomiting (in children)
- Diarrhea (in children)
- Infection (in children)
- Fever (in children)
- Abdominal pain (in children)
- Tremor (in children)
Pregnancy & Lactation
- Pregnancy Category C
- Excreted in human milk
- Consideration for discontinuation of nursing or drug
Precautions & Warnings
- Discontinue at first sign of rash
- Monitor for blood dyscrasias
- Monitor for suicidal behavior and ideation
- Monitor for signs of aseptic meningitis
Use in Special Populations
- Adjunctive treatment for partial onset seizures not demonstrated in very young pediatric patients (aged 1 to 24 months)
- Maintenance treatment for bipolar disorder not established in pediatric patients (aged 10 to 17 years)
Overdose Effects
- Ataxia
- Nystagmus
- Seizures
- Decreased level of consciousness
- Coma
- Intraventricular conduction delay
Therapeutic Class
- Primary anti-epileptic drugs
Storage Conditions
- Keep out of reach of children
- Store in a dry place
- Below 25°C temperature
- Protected from light