P-Gut 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 4.40 (7 x 10: ৳ 308.00)
Strip Price: ৳ 44.00

Medicine Details

Category Details
Generic Pantoprazole sodium
Company Globe pharmaceuticals ltd
Also available as
P gut 40 mg tablet P gut 40 mg injection

Indications

  • Peptic ulcer diseases
  • Gastroesophageal reflux diseases
  • Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
  • Eradication of Helicobacter pylori (in combination with antibiotics)
  • Zollinger-Ellison Syndrome

Pharmacology

Proton pump inhibitor, suppresses final step in gastric acid production, covalently binds to H+/K+ATPase enzyme system, inhibits both basal and stimulated gastric acid secretion

Dosage & Administration

  • Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed
  • Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed, maintenance dose is 20 mg daily, which may be increased to 40 mg daily
  • Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed
  • Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents for one week
  • Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for those requiring long-term NSAID treatment
  • Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response (elderly max. 40 mg daily); daily doses above 80 mg given in 2 divided doses
  • IV Injection: Dosages for duodenal ulcer, gastric ulcer, GERD, prevention of rebleeding, prophylaxis of acid aspiration, long-term management of Zollinger-Ellison Syndrome and pathological hypersecretory conditions

Interaction

No significant drug interactions observed in clinical studies

Contraindications

Contraindicated in patients with known hypersensitivity to any of the components of the formulation

Side Effects

  • Well tolerated in both short-term and long-term treatment
  • Common side effects: headache, diarrhea
  • Rare side effects: abdominal pain, flatulence, rash, insomnia, hyperglycemia

Pregnancy & Lactation

US FDA Pregnancy Category B, no adequate and well-controlled studies in pregnant women

Precautions & Warnings

  • Tablet should not be split, chewed or crushed
  • Long-term therapy may lead to malabsorption of cyanocobalamin (Vitamin B12) or increase risk of osteoporosis related disorders

Overdose Effects

No known symptoms of overdosage in humans, highly protein bound, not readily dialyzable

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

Instructions for reconstitution and administration of IV injection and IV infusion

Storage Conditions

Keep in a dry place, away from light and heat, keep out of the reach of children

Chemical Structure

  • Molecular Formula: C16H15F2N3O4S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-859-pantoprazole-sodium-chemical-structure-cnfmhAVGwpLzfJYlfu9P.svg

Common Questions about P-Gut 20 mg Tablet

  • Description of P-Gut 20 mg Tablet and its uses
  • Use duration for improvement in health conditions
  • Frequency of use
  • Instructions for empty stomach or before/after food usage
  • Storage and disposal instructions
  • Effects on older adults
  • Time taken for the medication to work
  • Safety considerations
  • Potential weight gain
  • Common side effects
  • Usage during pregnancy or breastfeeding
  • Actions to take if a dose is missed

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