Intez 2.5 mg (Tablet)

Indications

• Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer
• Treatment of advanced breast cancer in women with postmenopausal status
• First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer
• Pre-operative therapy in postmenopausal women with localized hormone receptor positive breast cancer

Pharmacology

• Potent and highly specific nonsteroidal aromatase inhibitor
• Inhibition of the aromatase enzyme
• Reduction of estrogen biosynthesis in all tissues
• Effects on estrogen biosynthesis in postmenopausal women
• Rapid and complete absorption from the gastrointestinal tract
• Plasma protein binding of approximately 60%

Dosage & Administration

• Recommended dose of 2.5 mg once daily
• Treatment duration of 5 years in certain cases
• No dose adjustment required for elderly patients or those with hepatic and/or renal impairment

Interaction

• No clinically significant interactions with cimetidine and warfarin

Contraindications

• Known or suspected hypersensitivity to letrozole or other aromatase inhibitors
• Contraindicated during pregnancy, lactation, and in pre-menopausal women
• Contraindicated in severe hepatic dysfunction

Side Effects

• Common side effects such as hot flushes, increased cholesterol levels, fatigue, pain in bones and joints, skin rash, headache, dizziness, gastrointestinal disorders
• Rare side effects including nervous disorders, memory problems, eye irritation, weight decrease, urinary tract infection

Pregnancy & Lactation

• Teratogenicity and maternal toxicity observed in pregnant rats
• Not recommended for use in pregnant women or nursing mothers

Precautions & Warnings

• No dosage adjustment necessary in breast cancer patients with moderate hepatic dysfunction
• Renal impairment did not affect plasma concentration at certain doses
• Potential risks of fatigue and dizziness should be considered
• Consideration for patients operating machinery or driving a car

Overdose Effects

• No clinical experience of overdosage
• No specific antidote available
• Supportive care and monitoring of vital signs recommended

Therapeutic Class

• Hormonal Chemotherapy

Storage Conditions

• Store below 30°C away from light and moisture
• Keep out of the reach of children

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