P-Gut 40 mg/vial (IV Injection)

40 mg vial: ৳ 70.00

Medicine Details

Category	Details
Generic	Pantoprazole sodium
Company	Globe pharmaceuticals ltd
Also available as	P gut 20 mg tablet P gut 40 mg tablet

Indications

Peptic ulcer diseases
Gastroesophageal reflux diseases
Ulcer induced by NSAIDs
Eradication of Helicobacter pylori
Zollinger-Ellison Syndrome

Pharmacology

Proton pump inhibitor that suppresses the final step in gastric acid production by binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell.

Dosage & Administration

Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed
Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed
Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed
Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at a dose of 40 mg twice daily in association with antimicrobial agents as detailed by the provider
Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for those requiring long-term NSAID treatment
Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response, elderly max. 40 mg daily
IV Injection for Duodenal ulcer and gastric ulcer: 40 mg once daily for 7-10 days
IV Injection for Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7-10 days
IV Injection for Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by 8 mg/hour infusion for 72 hours
IV Injection for Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, followed by 40mg every 12 hour
IV Injection for Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours, may increase to 80 mg every 8 hours if needed, may titrate to higher doses depending on acid output.

Interaction

No significant drug interactions observed in clinical studies

Contraindications

Patients with known hypersensitivity to any of the components of the formulation

Side Effects

Well tolerated in both short-term and long-term treatment
Common side effects: headache, diarrhea
Rare side effects: abdominal pain, flatulence, rash, insomnia, hyperglycemia

Pregnancy & Lactation

US FDA Pregnancy Category B. No adequate and well-controlled studies in pregnant women. Excreted in human milk. Use during pregnancy only if clearly needed

Precautions & Warnings

P-Gut tablet should not be split, chewed or crushed. Long-term therapy may lead to malabsorption of cyanocobalamin (Vitamin B12) or may increase the risk of osteoporosis related disorders

Overdose Effects

No known symptoms of overdosage in humans. P-Gut is highly protein bound and not readily dialyzable. Symptomatic and supportive management recommended

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

P-Gut IV injection should be given as a slow intravenous injection
Reconstituted solution may be stored at room temperature for a maximum 4 hours
Use freshly prepared solution
IV infusion should be given as an intravenous infusion over a period of approximately 15 minutes
Admixed solution may be stored at room temperature and must be used within 24 hours from the time of initial reconstitution

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children

Chemical Structure

Molecular Formula: C16H15F2N3O4S
Chemical Structure Image: https://medex.com.bd/storage/res/g-res-859-pantoprazole-sodium-chemical-structure-cnfmhAVGwpLzfJYlfu9P.svg

Common Questions & Answers

What is P-Gut 40 mg/vial Injection?: It is a proton pump inhibitor used to treat Peptic ulcer diseases, GERD, Ulcer induced by NSAIDs, Eradication of Helicobacter pylori, Zollinger-Ellison Syndrome
How long do I need to use P-Gut 40 mg/vial Injection before I see improvement in my condition?: It is to be taken until improvement is seen
At what frequency do I need to use P-Gut 40 mg/vial Injection?: As prescribed by the doctor
Should I use P-Gut 40 mg/vial Injection empty stomach, before food or after food?: Should be taken prior to the meal, approximately 30 minutes before it, in the prescribed dosage
What are the instructions for the storage and disposal of P-Gut 40 mg/vial Injection?: Should be kept in a cool dry place and in its original packaging. Make sure this medication remains unreachable to children and pets
What are the effects of P-Gut 40 mg/vial Injection in older adults?: May increase the risk for bone fractures, especially with longer use, higher doses in older adults. Consult your doctor about ways to prevent bone loss/fracture
How long does it take for P-Gut 40 mg/vial Injection to work?: Start to feel better within 2 to 3 days; may take up to 4 weeks for this medication to work properly
Is P-Gut 40 mg/vial Injection safe?: Relatively safe. Consult the doctor before consuming
Does P-Gut 40 mg/vial Injection cause weight gain?: In rare cases, can cause weight gain. Consult doctor for any weight-related concern
What are the side effects of P-Gut 40 mg/vial Injection?: Not common. Sometimes: headache, diarrhea, constipation, allergic reaction
Can I take P-Gut 40 mg/vial Injection if I am pregnant or breastfeeding?: Consult the doctor