Neurocet 500 mg (Tablet)

Unit Price: ৳ 30.00 (3 x 10: ৳ 900.00)
Strip Price: ৳ 300.00

Medicine Details

Category Details
Generic Levetiracetam
Company Incepta pharmaceuticals ltd
Also available as
Neurocet 250 mg tablet Neurocet 500 mg oral solution Neurocet 500 mg injection Neurocet xr 750 mg tablet Neurocet xr 500 mg tablet

Indications

  • Treatment of partial-onset seizures
  • Treatment of myoclonic seizures
  • Treatment of primary generalized tonic-clonic seizures
  • Monotherapy in adults and adolescents
  • Adjunctive therapy in adults, adolescents, children, and infants
  • Newly diagnosed epilepsy
  • Juvenile Myoclonic Epilepsy
  • Idiopathic Generalised Epilepsy

Description

  • Precise mechanism of action unknown
  • Minimal activity in submaximal stimulation
  • Protection against secondarily generalized activity
  • Inhibition of burst firing
  • Selective prevention of hyper synchronization

Dosage

  • Recommended starting dose of 250 mg twice daily for adults and adolescents
  • Initial therapeutic dose of 500 mg twice daily
  • Maximum dose of 1500 mg twice daily
  • Dose adjustments for pediatric population

Administration

  • Oral administration
  • Swallowed with liquid
  • Can be taken with or without food
  • Administered in two equally divided doses

Interaction

  • No influence on serum concentrations of existing antiepileptic medicinal products
  • No influence on pharmacokinetics of existing antiepileptic medicinal products
  • Interaction with Probenecid, Methotrexate, and Laxatives
  • No alteration of absorption by food
  • Slightly reduced rate of absorption by food
  • No available data on interaction with alcohol

Contraindications

  • Hypersensitivity to the active substance or other pyrrolidone derivatives or excipients

Side Effects

  • Most common adverse reactions
  • Incidence ≥ 5% more than placebo
  • Different adverse reactions in adult and pediatric patients

Pregnancy & Lactation

  • Not recommended during pregnancy
  • Not recommended during breastfeeding
  • Potential impact on fertility unknown
  • Clinical data on impact unknown

Precautions & Warnings

  • Dose adjustment for renal impairment
  • Rare cases of decreased blood cell counts
  • Potential association with acute kidney injury
  • Potential association with suicidal thoughts and behavior
  • Adapted formulation for pediatric population
  • Long term effects on pediatric population unknown

Use in Special Populations

  • Dose adjustment in elderly patients with compromised renal function
  • Individualized dose according to renal function
  • No dose adjustment in patients with mild to moderate hepatic impairment
  • Dose adjustment in severe hepatic impairment

Overdose Effects

  • Observation of somnolence, agitation, aggression, and respiratory depression
  • No specific antidote available
  • Symptomatic treatment required
  • Potential need for haemodialysis

Therapeutic Class

Adjunct anti-epileptic drugs

Storage Conditions

Store at a cool temperature (not exceeding 25°C), dry place, protected from light

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