Syndopa CR 100 mg+25 mg (Tablet (Controlled Release))

Unit Price: ৳ 10.03 (3 x 10: ৳ 300.90)
Strip Price: ৳ 100.30

Medicine Details

Category Details
Generic Levodopa carbidopa cr tablet
Company Sun pharmaceutical bangladesh ltd
Also available as
Syndopa cr 200 mg tablet

Indications

  • Idiopathic Parkinson's disease
  • Reducing off-period in patients previously treated with levodopa/decarboxylase inhibitors

Dosage

  • Substituting levodopa/carbidopa prolonged-release tablet initially at an amount providing no more than approximately 10% more levodopa per day
  • Prolonging dosing interval by 30 to 50% at intervals ranging from 4 to 12 hours
  • Titration based on clinical response
  • Necessary dosages providing up to 30% more levodopa per day
  • Conversion guideline from conventional levodopa/carbidopa tablet to controlled release tablet

Administration

  • Discontinuing levodopa at least eight hours before starting therapy
  • Adjusting doses and dosing intervals based on therapeutic response
  • Using 2 to 8 tablets per day administered as divided doses at intervals ranging from 4 to 12 hours
  • Maintenance with periodic clinical evaluations

Interaction

  • Caution with antihypertensive agents, antidepressants, anticholinergics, and iron
  • Potential reduction of therapeutic effects of levodopa with certain drugs
  • Observation for loss of therapeutic response with specific drug combinations

Contraindications

  • Contraindication with sympathomimetic amines
  • Non-selective monoamine oxidase (MAO) inhibitors contraindicated
  • Known hypersensitivity to any component
  • Narrow-angle glaucoma
  • Possible activation of malignant melanoma

Side Effects

  • Frequent dyskinesia
  • Incidence of dyskinesias higher than conventional tablet
  • Other side effects include nausea, hallucinations, confusion, dizziness, and more

Pregnancy & Lactation

  • Insufficient data for evaluation in human pregnancy
  • Unknown excretion of carbidopa in human milk
  • Not recommended during pregnancy and lactation

Precautions & Warnings

  • Discontinuation and cautious use in certain patient populations
  • Monitoring for involuntary movements, mental disturbances, and depression
  • Observation for impulse control disorders
  • Not recommended in patients below the age of 18

Use in Special Populations

  • Safety and effectiveness not established in patients below the age of 18

Therapeutic Class

  • Antiparkinson drugs

Storage Conditions

  • Store in a cool and dry place, protected from light

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