P-40 40 mg (Tablet (Enteric Coated))

Unit Price: ৳ 6.00 (50's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Pantoprazole sodium
Company Asiatic laboratories ltd
Also available as
P 20 20 mg tablet

Indications

  • Peptic ulcer diseases
  • Gastroesophageal reflux diseases
  • Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
  • Eradication of Helicobacter pylori (in combination with antibiotics)
  • Zollinger-Ellison Syndrome

Pharmacology

Pantoprazole is a proton pump inhibitor that suppresses the final step in gastric acid production by covalently binding to the H+/K+ATPase enzyme system at the surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus that persists longer than 24 hours.

Dosage & Administration

  • 40 mg daily in the morning for 4 weeks (benign gastric ulcer)
  • 20-40 mg daily in the morning for 4 weeks (gastro-esophageal reflux disease)
  • 40 mg daily in the morning for 2 weeks (duodenal ulcer)
  • 40 mg twice daily in association with antimicrobial agents for one week (duodenal ulcer associated with Helicobacter pylori)
  • 20 mg daily for long-term NSAID treatment (prophylaxis of NSAID-associated gastric or duodenal ulcer)
  • Initially 80 mg once daily adjusted according to response (Zollinger-Ellison Syndrome)

Interaction

No significant drug interactions observed in clinical studies.

Contraindications

Patients with known hypersensitivity to any of the components of the formulation.

Side Effects

  • Headache
  • Diarrhea
  • Abdominal pain
  • Flatulence
  • Rash
  • Insomnia
  • Hyperglycemia

Pregnancy & Lactation

US FDA Pregnancy Category B. Use during pregnancy only if clearly needed. Excreted in human milk.

Precautions & Warnings

  • Tablet should not be split, chewed or crushed
  • Long-term therapy may lead to malabsorption of cyanocobalamin (Vitamin B12) or may increase the risk of osteoporosis related disorders.

Overdose Effects

No known symptoms of overdosage in humans. Highly protein bound.

Therapeutic Class

Proton Pump Inhibitor

Reconstitution

IV injection to be given as a slow intravenous injection; IV infusion over a period of approximately 15 minutes.

Storage Conditions

Keep in a dry place, away from light and heat. Keep out of the reach of children.

Chemical Structure

Molecular Formula: C16H15F2N3O4S

Common Questions about P-40 40 mg Tablet

  • Proton pump inhibitor. Suppresses the final step in gastric acid production.
  • To be taken till the time improvement in health conditions is observed.
  • Should be taken in the dosage as prescribed by the doctor.
  • To be taken prior to the meal, approximately 30 minutes before it, in the prescribed dosage.
  • Should be kept in a cool dry place and in its original packaging. Ensure it remains unreachable to children and pets.
  • May increase the risk for bone fractures, especially with longer use, higher doses in older adults.
  • Start to feel better within 2 to 3 days, may take up to 4 weeks for full effect.
  • Relatively safe. Consult the doctor before consuming.
  • In rare cases, may cause weight gain. Consult your doctor for any weight-related concern.
  • Side effects: headache, diarrhea, constipation, allergic reaction.
  • Avoid unless prescribed by your doctor.
  • If missed, take it as soon as you remember, skip if close to the next dose.

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