Pansec 40 mg (Tablet (Enteric Coated))

Therapeutic Class

• Proton Pump Inhibitor

Indications

• Peptic ulcer diseases
• Gastroesophageal reflux diseases
• Ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs)
• Eradication of Helicobacter pylori (in combination with antibiotics)
• Zollinger-Ellison Syndrome

Pharmacology

• Proton pump inhibitor
• Suppresses final step in gastric acid production
• Covalently binds to the H+/K+ ATPase enzyme system
• Inhibition of both basal and stimulated gastric acid secretion

Dosage & Administration

• Benign gastric ulcer: 40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed
• Gastro-esophageal reflux disease: 20-40 mg daily in the morning for 4 weeks, continued for further 4 weeks if not fully healed
• Duodenal ulcer: 40 mg daily in the morning for 2 weeks, continued for further 2 weeks if not fully healed
• Duodenal ulcer associated with Helicobacter pylori: 40 mg twice daily in association with antimicrobial agents for one week
• Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily
• Zollinger-Ellison Syndrome: Initially 80 mg once daily adjusted according to response

Interaction

• No significant drug interactions observed in clinical studies

Contraindications

• Known hypersensitivity to any of the components of the formulation

Side Effects

• Well tolerated
• Common side effects: headache, diarrhea
• Rare side effects: abdominal pain, flatulence, rash, insomnia, hyperglycemia

Pregnancy & Lactation

• US FDA Pregnancy Category B
• No adequate and well-controlled studies in pregnant women
• Excreted in human milk
• Decision to use during pregnancy should consider benefit to the mother

Precautions & Warnings

• Tablet should not be split, chewed or crushed
• Long-term therapy may lead to malabsorption of cyanocobalamin (Vitamin B12)
• May increase risk of osteoporosis related disorders

Overdose Effects

• No known symptoms of overdosage in humans
• Not readily dialyzable
• Symptomatic and supportive management recommended

Reconstitution

• IV injection: given slowly over a period of at least 2 to 5 minutes
• IV infusion: given over a period of approximately 15 minutes
• Reconstituted solution may be stored at room temperature for a maximum of 4 hours prior to further dilution

Storage Conditions

• Keep in a dry place, away from light and heat
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C16H15F2N3O4S
• Chemical Structure Image: https://medex.com.bd/storage/res/g-res-859-pantoprazole-sodium-chemical-structure-cnfmhAVGwpLzfJYlfu9P.svg

Commonly Asked Questions

• What is Pansec 40 mg Tablet?
• How long do I need to use Pansec 40 mg Tablet before I see improvement in my condition?
• At what frequency do I need to use Pansec 40 mg Tablet?
• Should I use Pansec 40 mg Tablet empty stomach, before food or after food?
• What are the instructions for the storage and disposal of Pansec 40 mg Tablet?
• What are the effects of Pansec 40 mg Tablet on older adults?
• How long does it take for Pansec 40 mg Tablet to work?
• Is Pansec 40 mg Tablet safe?
• Does Pansec 40 mg Tablet cause weight gain?
• What are the side effects of Pansec 40 mg Tablet?
• Can I take Pansec 40 mg Tablet if I am pregnant or breastfeeding?
• What should I do if I miss a dose of Pansec 40 mg Tablet?

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